证据权重法在双酚A人群流行病学数据危害评估中的应用研究  

Application of weight of evidence approach in hazard assessment of human epidemiological data of bisphenol A

作　　者：熊围 于梦淇 曹莉 田林 陈锦瑶[1] 隋海霞 李晓蒙 杨道远 XIONG Wei;YU Mengqi;CAO Li;TIAN Lin;CHEN Jinyao;SUI Haixia;LI Xiaomeng;YANG Daoyuan(West China School of Public Health,Sichuan University,Food Safety Monitoring and Risk Assessment Key Laboratory of Sichuan Province,Sichuan Chengdu 610041,China;China National Center for Food Safety Risk Assessment,Beijing 100022,China)

机构地区：[1]四川大学华西公共卫生学院,食品安全监测与风险评估四川省重点实验室,四川成都610041 [2]国家食品安全风险评估中心,北京100022

出　　处：《中国食品卫生杂志》2022年第5期947-956,共10页Chinese Journal of Food Hygiene

基　　金：国家自然科学基金(32061160474)。

摘　　要：目的 使用证据权重法对双酚A(BPA)人群流行病学数据进行评估,推断BPA暴露与人体不良健康效应之间的关系。方法 基于证据权重法,对2013—2020年发表的BPA人群流行病学文献进行系统检索、筛选、分类,依据国家食品安全风险评估中心制定的毒理学数据相关性与可靠性评价指南进行评价,按不同毒性效应终点进行危害评估。结果 对检索的134 897篇文献进行筛选后共获得文献188篇,其中68篇文献相关性评价等级为“A/B”或“B”,其余文献相关性评价等级为“C”。仅对相关性评价等级为“A/B”或“B”的文献进行可靠性评价,其中6篇文献可靠性评价等级为“高”,62篇文献可靠性评价等级为“中”,涉及的毒性效应终点包括代谢、生殖发育、神经、免疫、心血管效应等,但各研究结局由于人群、暴露期限、指标设计等原因,具有一致性的效应指标较少。结论 基于现有人群流行病学证据,尚无法明确BPA暴露与人体不良健康效应之间的因果关系。Objective To infer the relationship between bisphenol A(BPA)exposure and adverse health effects in humans,the human epidemiological data of BPA was evaluated by the weight of evidence approach.Methods Based on the weight of evidence approach,the human epidemiological research articles on BPA published between 2013 and 2020were systematically searched,screened and classified. The selected articles were evaluated following the guidelines of evaluating the relevance and reliability of toxicological data developed by the China National Center for Food Safety Risk Assessment. The hazard assessment was performed based on different endpoints.Results A total of 188 papers were obtained screening from 134 897 records,of which 68 papers were evaluated as “A/B” or “B” in terms of relevance,and the rest were evaluated as “C”. Only the studies with the relevance evaluation grade of “A/B” or “B” were evaluated for reliability,of which 6 studies were evaluated as “high” reliability and 62 studies were evaluated as “medium” reliability.The endpoints of toxicological effects should include metabolic, reproductive and developmental, neurological,immunological and cardiovascular effects. However,the effect indicators across studies lacked consistency due to study population, exposure duration and indicator design.Conclusion Based on the available evidence of human epidemiological data,the relationship between BPA exposure and adverse health effects in humans is not yet clear.

关 键 词：证据权重法 双酚A 流行病学研究 危害评估 

分 类 号：R155[医药卫生—营养与食品卫生学]