磷脂酰丝氨酸对缺血性卒中神经保护作用的研究进展  

Research progress on neuroprotective effect of phosphatidylserine in ischemic stroke

作　　者：郭佳琦 段云霞[1] 徐率立 吴迪[1] Guo Jiaqi;Duan Yunxia;Xu Shuaili;Wu DiChina(America Institute of Neuroscience,Xuanwu Hospital,Capital Medical University,Beijing 100053,China)

机构地区：[1]首都医科大学宣武医院中美神经科学研究所,北京100053

出　　处：《中国脑血管病杂志》2023年第1期54-57,共4页Chinese Journal of Cerebrovascular Diseases

基　　金：国家自然科学基金(82071466、81871022)。

摘　　要：缺血性卒中具有高发病率、高复发率、高致残率和病死率的特点。缺血半暗带组织是缺血性卒中患者再通治疗后临床获益的关键。减少缺血半暗带组织神经细胞的凋亡,可能改善缺血性卒中的预后。磷脂酰丝氨酸作为介导细胞凋亡最重要的“eat me”信号,或可成为神经保护的新靶点,为卒中后神经保护提供新思路。作者对磷脂酰丝氨酸对缺血性卒中的神经保护作用的研究进展进行综述。Ischemic stroke is characterized by high morbidity, high recurrence, high disability and mortality. The existence of ischemic penumbra is the key to better clinic outcomes after recanalization in patients with ischemic stroke. Reducing neurons′ apoptosis in the ischemic penumbra is important for improving the prognosis of ischemic stroke. Phosphatidylserine, as the well-known “eat me” signal mediating apoptosis, may become a new target for neuroprotection. This new target will provide new insight for neuroprotection after stroke. The article reviewed the research progress of the neuroprotective effect by reducing phosphatidylserine after ischemic stroke.

关 键 词：卒中 细胞凋亡 缺血半暗带 磷脂酰丝氨酸 综述 

分 类 号：R743.3[医药卫生—神经病学与精神病学]