胆汁酸受体TGR5介导的糖脂代谢在非酒精性脂肪性肝病中的作用  

Role of glucose and lipid metabolism mediated by the bile acid receptor Takeda G protein-coupled receptor 5 in nonalcoholic fatty liver disease

作　　者：荀小霞 周铖 赵文霞[2] XUN Xiaoxia;ZHOU Cheng;ZHAO Wenxia(The First Clinical Medical College of Henan University of Chinese Medicine,Zhengzhou 450000,China;Department of Hepatology and Spleen-Stomach,The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学第一临床医学院,郑州450000 [2]河南中医药大学第一附属医院脾胃肝胆科,郑州450000

出　　处：《临床肝胆病杂志》2023年第1期162-167,共6页Journal of Clinical Hepatology

基　　金：国家自然科学基金面上项目(81473651);河南省中医药科学研究专项课题(2018JDZX005,2019JDZX2051);河南省科技攻关计划项目(202102310495);河南省特色骨干学科中医学学科建设项目(STG-ZYXKY-2020024)。

摘　　要：非酒精性脂肪性肝病(NAFLD)逐渐成为影响人类肝脏健康的主要原因,其发生发展与代谢功能障碍相关,糖脂代谢紊乱是其中的关键环节。武田G蛋白偶联受体5(TGR5)是胆汁酸的主要受体之一,在体内广泛表达,其介导的糖脂代谢在人体发挥重要作用。本文总结了TGR5在糖脂代谢中的作用和机制,以及基于TGR5治疗NAFLD的研究成果,以期对基础和临床研究提供参考。Nonalcoholic fatty liver disease(NAFLD)has gradually become a prominent cause affecting human liver health,and the development and progression of NAFLD are associated with metabolic dysfunction,with glucose and lipid metabolism disorder as the key link in this process.Takeda G protein-coupled receptor 5(TGR5)is one of the main receptors of bile acid and is extensively expressed in the body,and glucose and lipid metabolism mediated by TGR5 plays an important role in the human body.This article summarizes the role and mechanism of TGR5 in glucose and lipid metabolism and the research findings of the treatment of NAFLD based on TGR5,in order to provide a reference for basic and clinical research.

关 键 词：受体 G-蛋白偶联 碳水化合物代谢 脂类代谢 非酒精性脂肪性肝病 

分 类 号：R575.5[医药卫生—消化系统]