基于“虚、瘀、毒”理论探讨结直肠炎-癌转化机制  

Discussion on the mechanism of colorectitis-cancer transformation based on the theory of"deficiency,blood stasis and toxin"

作　　者：王方园 杨玉莹 王栋 时浩洋 赵爽[1] 孟静岩[1] WANG Fangyuan;YANG Yuying;WANG Dong;SHI Haoyang;ZHAO Shuang;MENG Jingyan(Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学,天津301617

出　　处：《吉林中医药》2023年第1期18-23,共6页Jilin Journal of Chinese Medicine

基　　金：国家自然科学基金资助项目(81973728);天津市自然科学基金资助项目(18JCZDJC36600)。

摘　　要：中医认为结直肠炎-癌转化病机以正虚邪实为主,治疗应以扶正祛邪为要。长期的慢性炎症刺激导致的炎-癌转化是癌症发生的重要机制之一,研究“炎-癌转化”的发生发展机制对阻断癌症的发展进程有重要意义。从中医“虚、瘀、毒”的角度结合现代医学对结直肠炎-癌转化的认识,以扶正、活血、解毒为治疗原则,扶正补虚,提高机体免疫抗邪能力,在炎症期切断炎-癌转化进程。Traditional Chinese medicine believes that the pathogenesis for the transformation from colorectitis to colorectal cancer lies mainly in the excess of pathogenic factors due to the deficiency of vital qi,and its treatment should focus on strengthening the vital qi and eliminating pathogenic factors.The transformation from inflammation to cancer caused by a long-term chronic inflammatory stimulation is one of the important mechanisms for cancer development.Accordingly,it is important to study the mechanism of"inflammation-cancer transformation"to block the development process.This paper aims to discuss the mechanism and evolution of colorectitis-to-colorectal cancer transformation from the perspective of"deficiency,blood stasis and toxicity"in Chinese medicine in combination with the modern medical knowledge,proposing the treatment principles of strengthening the vital qi,promoting blood circulation and detoxifying,so as to provide new ideas for preventing or delaying the occurrence of colorectal cancer.

关 键 词：结直肠炎-癌转化 病机演变 扶正 活血 解毒 

分 类 号：R735.3[医药卫生—肿瘤]