盐酸米诺环素联合Vitapex糊剂根管充填治疗老年慢性牙周炎合并牙髓病变患者的效果  

Effects of Minocycline hydrochloride combined with Vitapex paste root canal filling in treatment of elderly patients with chronic periodontitis combined with pulp lesions

作　　者：郑秋玉 ZHENG Qiuyu(Department of Stomatology of Liaoning Maternal and Child Health Hospital,Shenyang 110000 Liaoning,China)

机构地区：[1]辽宁省妇幼保健院口腔科,辽宁沈阳110000

出　　处：《中国民康医学》2023年第1期69-72,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察盐酸米诺环素联合Vitapex糊剂根管充填治疗老年慢性牙周炎合并牙髓病变患者的效果。方法:选取2019年1月至2021年6月该院收治的86例(100颗)慢性牙周炎合并牙髓病变患者进行前瞻性研究,根据随机数字表法将其分为研究组43例(50颗)和对照组43例(50颗),对照组采用Vitapex糊剂根管充填治疗,研究组在对照组基础上联合盐酸米诺环素治疗,比较两组治疗前后牙周指标[牙周探诊深度(PD)、牙龈出血指数(BI)、牙龈指数(GI)、菌斑指数(PLI)]水平、炎性因子[白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)]水平、临床疗效和不良反应发生率。结果:治疗后,两组PD、BI、GI、PLI水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组IL-6、IL-8、TNF-α水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);研究组治疗总有效率为93.02%(40/43),高于对照组的76.74%(30/43),差异有统计学意义(P<0.05);治疗期间,两组均未见明显不良反应。结论:盐酸米诺环素联合Vitapex糊剂根管填充治疗慢性牙周炎伴牙髓病变患者可提高治疗总有效率,降低炎性因子和牙周指标水平,其效果优于单纯Vitapex糊剂根管充填治疗。Objective: To observe effects of Minocycline hydrochloride combined with Vitapex paste root canal filling in treatment of elderly patients with chronic periodontitis combined with pulp lesions. Methods: A prospective study was conducted on 86 patients(100 teeth) with chronic periodontitis combined with pulp lesions admitted to the hospital from January 2019 to June 2021. According to the random number table method, they were divided into study group(43 cases, 50 teeth) and control group(43 cases, 50 teeth). The control group was treated with Vitapex paste root canal filling, while the study group was treated with Minocycline hydrochloride on the basis of that of the control group. The levels of periodontal indexes [periodontal probing depth(PD), gingival bleeding index(BI), gingival index(GI), plaque index(PLI)], the inflammatory factor levels [interleukin-6(IL-6), interleukin-8(IL-8), tumor necrosis factor-α(TNF-α)], the clinical efficacy, and the incidence of adverse reactions were compared between the two groups before and after the treatment. Results: After the treatment, the levels of PD, BI, GI and PLI in the two groups were lower than those before the treatment, those in the study group were lower than those in the control group, and the differences were statistically significant(P<0.05). The levels of IL-6, IL-8 and TNF-α in the two groups were lower than those before the treatment, those in the the study group were lower than those in the control group, and the differences were statistically significant(P<0.05). The total effective rate of treatment in the study group was 93.02%, which was higher than 76.74% in the control group, and the difference was statistically significant(P<0.05). During the treatment,there were no obvious adverse reactions in the two groups. Conclusions: Minocycline hydrochloride combined with Vitapex paste root canal filling can improve the total effective rate of treatment and reduce the levels of inflammatory factors and the periodontal indexes in the patients with chronic p

关 键 词：慢性牙周炎合并牙髓病变 盐酸米诺环素 VITAPEX糊剂 根管充填 炎性因子 牙周 不良反应 

分 类 号：R781.4[医药卫生—口腔医学]