lncRNA在胃癌中作用及其机制的研究进展  

Advances in the role and mechanism of lncRNA in gastric cancer

作　　者：袁玉刚 李学良[2] YUAN Yugang;LI Xueliang(Nanjing Medical University,Nanjing 211166;Department of Gastroenterology,the First Affiliated Hospital of Nanjing Medical University,China)

机构地区：[1]南京医科大学,江苏南京211166 [2]南京医科大学第一附属医院消化内科

出　　处：《胃肠病学和肝病学杂志》2022年第12期1335-1341,共7页Chinese Journal of Gastroenterology and Hepatology

摘　　要：胃癌是一种临床常见的恶性肿瘤,早期诊断困难,进展期时出现侵袭、转移等恶性行为,治疗方式欠缺,预后较差。据研究,长链非编码RNA(long non-coding RNA,lncRNA)在进展期胃癌靶向治疗及化疗疗效等方面有着重要作用。本文就lncRNA在胃癌发生发展及治疗中的研究作一概述,以期为今后胃癌的早期诊断及临床治疗提供更多思路。Gastric cancer is a common malignant tumor in clinical practice.Its early diagnosis is difficult,and malignant behaviors such as invasion and metastasis occur in the advanced stage.It is characterized by poor treatment methods and poor prognosis.Long non-coding RNA(lncRNA)plays an important role in targeted therapy and chemotherapy efficacy of advanced gastric cancer.In this article,the research of lncRNA in the occurrence,development and treatment of gastric cancer was briefly summarized,in order to provide more ideas for the early diagnosis and clinical treatment of gastric cancer in the future.

关 键 词：胃癌 lncRNA 生物标志物 诊断与治疗 

分 类 号：R735.2[医药卫生—肿瘤]