色氨酸及其衍生物在炎症性肠病中的研究进展  

Research progress of tryptophan and its derivatives in inflammatory bowel disease

作　　者：陈文轩 张哲 周川[1] 王素敏[1] 王亮 冯百岁[1] CHEN Wenxuan;ZHANG Zhe;ZHOU Chuan;WANG Sumin;WANG Liang;FENG Baisui(Department of Gastroenterology,the Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450014,China)

机构地区：[1]郑州大学第二附属医院消化内科,河南郑州450014

出　　处：《胃肠病学和肝病学杂志》2022年第12期1424-1427,共4页Chinese Journal of Gastroenterology and Hepatology

基　　金：郑州大学前沿交叉研究专项项目(XKZDQY201906);河南省重点研发与推广专项(科技攻关)(212102310803);2021年度郑州市科技惠民计划项目(2021KJHM0018);河南省医学科技攻关(联合共建)项目(2018020154,LHGJ20200399,LHGJ20210416)。

摘　　要：炎症性肠病(inflammatory bowel disease,IBD)是一组主要影响胃肠道的免疫相关性疾病,近年来在我国的发病率逐年增加,可能与多因素导致的肠黏膜屏障功能受损有关。色氨酸及其衍生物,通过与芳基烃受体(Aryl hydrocarbon receptor,AhR)等结合,能够加强机械屏障、稳定免疫屏障、维持化学屏障和恢复微生物屏障,在维持IBD肠道屏障完整性方面发挥着重要的作用。本文就色氨酸及其衍生物在IBD中的研究进展作一综述。Inflammatory bowel disease(IBD)is a group of autoimmune diseases mainly affecting the gastrointestinal tract.In recent years,the incidence of IBD is increasing year by year in China,which may be related to the impairment of intestinal mucosal barrier function caused by multiple pathways.Tryptophan and its derivatives can strengthen the mechanical barrier,stabilize the immune barrier,maintain the chemical barrier and restore the microbial barrier by binding with Aryl hydrocarbon receptor(AhR)and other receptors,and play an important role in maintaining the integrity of the intestinal barrier.This paper reviewed the research progress of tryptophan and its derivatives in IBD.

关 键 词：色氨酸 炎症性肠病 吲哚 犬尿氨酸 5-羟色胺 肠黏膜屏障 

分 类 号：R574[医药卫生—消化系统]