抗Hu抗体相关副肿瘤综合征合并吉兰-巴雷综合征1例并文献复习  

Anti-Hu antibody-associated paraneoplastic syndrome combined with Guillain-Barrésyndrome:A case and literature review

作　　者：林家煜[1] 张金英[2] 陈丽君 LIN Jia-Yu;ZHANG Jin-Ying;CHEN Li-Jun(Department of Endocrinology,The Second Affiliated Hospital of Fujian Medical University,Quanzhou,Fujian 362000,China;Department of Neurology,The Second Affiliated Hospital of Fujian Medical University Quanzhou,Fujian 362000,China)

机构地区：[1]福建医科大学附属第二医院内分泌科,福建泉州362000 [2]福建医科大学附属第二医院神经内科,福建泉州362000

出　　处：《国际神经病学神经外科学杂志》2022年第6期65-69,共5页Journal of International Neurology and Neurosurgery

基　　金：福建医科大学校启航基金项目(2020QH1122);福建医科大学校启航基金项目(2018QH1105)。

摘　　要：报道1例抗Hu阳性副肿瘤综合征(PNS)合并吉兰-巴雷综合征(GBS)患者的临床资料,患者男性,71岁,以急性起病的四肢瘫痪为临床表现,检验及检查结果符合抗利尿激素分泌失调综合征(SIADH)、GBS。血清Hu抗体阳性,PET-CT筛查考虑肺癌可能,病理证实为小细胞肺癌。给予激素、环磷酰胺及肿瘤治疗(依托泊苷+顺铂方案)后患者症状稍改善,但之后进展恶化,最后因呼吸衰竭死亡。临床上,对于中年以上的患者,以周围神经病变或顽固性低钠血症为主要表现,不能完全用其他疾病解释时,应警惕该病的可能,需进行隐匿性肿瘤的筛查。This article reports the clinical data of a patient with anti-Hu-positive paraneoplastic syndrome combined with Guillain-Barrésyndrome(GBS).The male patient,aged 71 years,had the clinical manifestation of the acute onset of tetraplegia,and testing and examination results were consistent with syndrome of inappropriate antidiuretic hormone secretion and GBS.Serum anti-Hu antibody was positive,and PET-CT screening considered the possibility of lung cancer;finally small cell lung cancer was confirmed by pathology.The patient was improved slightly after the administration of hormone,cyclophosphamide,and oncological therapy(etoposide+cisplatin),but then his conditions progressed and worsened,and finally the patient died due to respiratory failure.In clinical practice,the possibility of this disease should be considered for middle-aged or older patients with peripheral neuropathy or intractable hyponatremia as the main manifestation,which cannot be completely explained by other diseases,and such patients need to be screened for occult tumors.

关 键 词：副肿瘤综合征 抗利尿激素分泌失调综合征 吉兰-巴雷综合征 小细胞肺癌 

分 类 号：R739.41[医药卫生—肿瘤]