多发性硬化神经功能评估的研究进展  

Research advances in neurological assessment in multiple sclerosis

作　　者：薛雅慧 彭永 饶桂兰 何顺清 唐艳丹 谷文萍[3] XUE Ya-Hui;PENG Yong;RAO Gui-Lan;HE Shun-Qing;TANG Yan-Dan;GU Wen-Ping(Department of Neurology,Affiliated Hunan Provincial Chinese Medical hospital,Zhuzhou,Hunan 412000,China;Department of Neurology,Affiliated First Hospital of Hunan Traditional Chinese Medical College,Hunan University of Chinese Medicine,Zhuzhou,Hunan 412000,China;Department of Neurology,Xiangya Hospital,Central South University,Changsha,Hunan 410008,China)

机构地区：[1]湖南中医药大学附属省直中医院神经内科,湖南株洲412000 [2]湖南中医药高等专科学校附属第一医院神经内科,湖南株洲412000 [3]中南大学湘雅医院神经内科,湖南长沙410008

出　　处：《国际神经病学神经外科学杂志》2022年第6期87-91,共5页Journal of International Neurology and Neurosurgery

基　　金：湖南省中医药管理局重点课题(201915);湖南省自然科学基金(2018JJ6043);湖南省自然科学基金(2020JJ4875);湖南省卫计委课题(B20180815);株洲市科技局课题(2021-009);湖南中医药高等专科学校附属第一医院优秀科研创新团队(B2021-003);湖南省重点研发(2020SK2069)。

摘　　要：多发性硬化(MS)是中枢神经系统(CNS)最常见的慢性炎症性疾病,全球有200多万人受其影响。病理特征为弥漫性和局灶性炎症、脱髓鞘、胶质增生以及视神经、大脑和脊髓的神经元损伤。世界范围内MS的发病率和流行率都在增加。在疾病早期,40%~65%的MS患者患有认知功能障碍,从MS的认知功能障碍长期被忽视来看,神经心理及相关皮质损害检查很重要。该文主要总结了MS神经心理学的主要表现,包括记忆障碍、认知功能损伤、焦虑抑郁症状以及上肢功能的损伤,并讨论了MS神经功能评估的研究进展,主要是扩展残疾状态量表和多发性硬化复合功能量表。我们希望通过讨论MS神经功能评估量表的优缺点,总结更好的评估MS疾病进展的方式,从而帮助MS患者在更早的疾病轨迹中得到诊断和治疗。Multiple sclerosis(MS)is the most common chronic inflammatory disease of the central nervous system(CNS),affecting more than 2 million people worldwide.The pathological features of MS include diffuse and focal inflammation,demyelination,gliosis,and neuronal damage in the optic nerve,brain,and spinal cord.The incidence and prevalence rates of MS have been increasing in the world.In the early stage of MS,40%-65%of patients suffer from cognitive impairment,and due to the fact that cognitive impairment of MS has been ignored for a long time,it is of great importance to perform neuropsychological and cortical damage examinations.This article summarizes the main neuropsychological manifestations of MS,including memory impairment,cognitive impairment,anxiety and depression symptoms,and upper limb function impairment,and discusses the research advances in neurological assessment in MS,especially Expanded Disability Status Scale and Multiple Sclerosis Functional Composite.We hope to find better ways for evaluating the progression of MS by discussing the advantages and disadvantages of MS neurological scales,so as to help MS patients obtain diagnosis and treatment in the earlier stage of the disease.

关 键 词：多发性硬化 神经心理学 肢体功能 

分 类 号：R744.51[医药卫生—神经病学与精神病学]