血清Nogo-A、MIP-1α、MIP-1β在高血压脑出血患者中的表达及预后预测价值  

Expression and prognosis prediction value of serum Nogo-A,MIP-1αand MIP-1βin patients with hypertensive cerebral hemorrhage

作　　者：曹亮 崔旭波 CAO Liang;CUI Xubo(Neurosurgery Department,People′s Hospital of Tongchuan,Tongchuan,Shaanxi 727000,China)

机构地区：[1]陕西省铜川市人民医院神经外科,陕西铜川727000

出　　处：《检验医学与临床》2023年第3期299-302,共4页Laboratory Medicine and Clinic

摘　　要：目的探讨血清神经轴突生长抑制因子A(Nogo-A)、巨噬细胞炎症蛋白-1α(MIP-1α)、MIP-1β在高血压脑出血患者中的表达及预后预测价值。方法选择2016年3月至2021年12月该院收治的110例高血压脑出血患者作为高血压脑出血组,根据格拉斯哥昏迷量表(GCS)评分将其分为轻度组(35例)、中度组(46例)和重度组(29例),根据格拉斯哥预后评分将其分为预后良好组(79例)和预后不良组(31例)。检测高血压脑出血患者血清Nogo-A、MIP-1α、MIP-1β水平,并与同期150例单纯高血压患者(单纯高血压组)和100例健康志愿者(健康对照组)进行比较。结果与单纯高血压组和健康对照组比较,高血压脑出血组的血清Nogo-A、MIP-1α、MIP-1β水平明显升高(P<0.05)。与轻度组比较,中度组和重度组的血清Nogo-A、MIP-1α、MIP-1β水平明显升高(P<0.05)。与中度组比较,重度组的血清MIP-1β水平明显升高(P<0.05),而两组血清Nogo-A、MIP-1α水平比较,差异无统计学意义(P>0.05)。与血肿量<30 mL组比较,30~50 mL组和>50 mL组的血清MIP-1α、MIP-1β水平明显升高(P<0.05);而30~50 mL组和>50 mL组之间比较,差异无统计学意义(P>0.05)。与预后良好组比较,预后不良组的GCS评分13~15分比例、血肿破入脑室的比例明显提高(P<0.05),血清Nogo-A、MIP-1α、MIP-1β水平明显升高(P<0.05)。GCS评分、破入脑室、血清Nogo-A、MIP-1α、MIP-1β是高血压脑出血患者预后不良的影响因素(P<0.05)。Nogo-A、MIP-1α、MIP-1β联合预测高血压脑出血预后不良的灵敏度为86.69%,特异度为83.19%,AUC为0.858,明显高于Nogo-A、MIP-1α、MIP-1β单独检测。结论血清Nogo-A、MIP-1α、MIP-1β在高血压脑出血的评估及预测预后方面具有潜在价值,三者联合检测预测高血压脑出血预后不良的价值较高。Objective To explore the expression and prognostic prediction value of serum neurite growth inhibitor A(Nogo-A),macrophage inflammatory protein-1α(MIP-1α)and MIP-1βin patients with hypertensive cerebral hemorrhage.Methods A total of 110 patients with hypertensive intracerebral hemorrhage in People′s Hospital of Tongchuan from March 2016 to December 2021 were selected as the hypertensive intracerebral hemorrhage group,which was subdivided into mild group(n=35),moderate group(n=46)and severe group(n=29)according to the scores of Glasgow coma scale(GCS),and the good prognosis group(n=79)and the poor prognosis group(n=31)according to the scores of Glasgow outcome scale.The expression levels of serum Nogo-A,MIP-1αand MIP-1βwere detected in the hypertensive intracerebral hemorrhage group,and compared with 150 patients with simple hypertension(the simple hypertension group)and 100 healthy controls(the healthy control group)in the hospital during the same period.Results Compared with the simple hypertension group and the healthy control group,the expression levels of serum Nogo-A,MIP-1αand MIP-1βin the hypertensive intracerebral hemorrhage group increased significantly(P<0.05).Compared with the mild group,the expression levels of serum Nogo-A,MIP-1αand MIP-1βin the moderate group and the severe group increased significantly(P<0.05).Compared with the moderate group,the expression level of serum MIP-1βin the severe group increased significantly(P<0.05),while the difference had no statistical significance in expression levels of serum Nogo-A and MIP-1αbetween the two groups(P>0.05).Compared with the hematoma volume<30 mL group,the expression levels of serum MIP-1αand MIP-1βin the 30-50 mL group and>50 mL group increased significantly(P<0.05),but there was no significant difference between the 30-50 mL group and>50 mL group(P>0.05).Compared with the good prognosis group,the proportion with 13-15 GCS score and the proportion of hematoma ruptured into the ventricle were significantly improved(P<0.05),and the exp

关 键 词：高血压脑出血 神经轴突生长抑制因子A 巨噬细胞炎症蛋白 

分 类 号：R743.2[医药卫生—神经病学与精神病学]