血清β-Klotho、FGF-19和FGFR-4检测对分化型甲状腺癌的诊断价值  

Diagnostic value of serumβ-Klotho,FGF-19 and FGFR-4 detection in differentiated thyroid cancer

作　　者：王晔龙 于海文 WANG Yelong;YU Haiwen(Department of General Surgery,Shanghai Jiading District Nanxiang Hospital,Shanghai 201802,China)

机构地区：[1]上海市嘉定区南翔医院普外科,上海201802

出　　处：《检验医学与临床》2023年第3期374-378,共5页Laboratory Medicine and Clinic

摘　　要：目的观察血清β-Klotho、成纤维生长因子19(FGF-19)和成纤维生长因子受体4(FGFR-4)检测对分化型甲状腺癌的辅助诊断价值。方法选择2019年1月至2021年12月在该院确诊为分化型甲状腺癌患者98例纳入甲状腺癌组;选择同期该院收治的甲状腺良性肿瘤患者36例纳入良性病变组。观察两组血清β-Klotho、FGF-19和FGFR-4水平,探讨血清β-Klotho、FGF-19和FGFR-4水平与临床指标的关系,以及其对甲状腺癌的诊断效能和各指标之间的相关性。结果入院时甲状腺癌组血清β-Klotho水平明显低于良性病变组(P<0.05),而血清FGF-19和FGFR-4水平明显高于良性病变组(P<0.05)。术后,两组血清β-Klotho水平较入院时明显升高(P<0.05),而血清FGF-19和FGFR-4水平较入院时明显降低(P<0.05)。术后两组血清β-Klotho、FGF-19和FGFR-4水平比较,差异无统计学意义(P>0.05)。血清β-Klotho、FGF-19和FGFR-4水平在淋巴结转移、浸润深度和TNM分期方面比较,差异有统计学意义(P<0.05),在年龄、性别、分化程度、组织类型和肿瘤最大径方面比较,差异无统计学意义(P>0.05)。血清β-Klotho、FGF-19和FGFR-4检测对甲状腺癌具有较高的辅助诊断效能,联合检测的灵敏度为80.6%,特异度为97.2%,曲线下面积(0.944)明显高于β-Klotho、FGF-19和FGFR-4单独检测(Z=3.307、3.953、4.477,P<0.05)。甲状腺癌患者血清β-Klotho水平与FGF-19和FGFR-4水平呈负相关(r=-0.732、-0.648,P<0.05),而血清FGF-19水平与FGFR-4水平呈正相关(r=0.816,P<0.05)。结论β-Klotho、FGF-19和FGFR-4参与了甲状腺癌的发病过程,联合检测有助于提高对甲状腺癌的辅助诊断效能。Objective To observe the auxiliary diagnostic value of serumβ-Klotho,fibroblast growth factor 19(FGF-19)and fibroblast growth factor receptor 4(FGFR-4)detection in differentiated thyroid cancer.Methods A total of 98 patients with differentiated thyroid cancer diagnosed in Shanghai Jiading District Nanxiang Hospital from January 2019 to December 2021 were selected as the thyroid cancer group,36 patients with benign thyroid tumors in the hospital during the same period were selected as the benign lesion group.The levels of serumβ-Klotho,FGF-19 and FGFR-4 were observed in the two groups,the relation was observed between the serumβ-Klotho,FGF-19 and FGFR-4 levels and clinical indicators,the diagnostic efficacy of those indicators was observed in diagnosis of thyroid cancer,and the correlation analysis was also observed among each indicator.Results At admission,the level of serumβ-Klotho in the thyroid cancer group was significantly lower than that in the benign lesion group(P<0.05),while the levels of serum FGF-19 and FGFR-4 were significantly higher that those in the benign lesion group(P<0.05).After surgery,the level of serumβ-Klotho in both groups was significantly higher than that at admission(P<0.05),while the levels of serum FGF-19 and FGFR-4 were significantly lower than those at admission(P<0.05).The levels of serumβ-Klotho,FGF-19 and FGFR-4 had no significantly difference between the two groups after surgery(P>0.05).The serumβ-Klotho,FGF-19 and FGFR-4 levels were significantly different from lymph node metastasis,depth of invasion and TNM stage(P<0.05),but not significantly different from age,gender,degree of differentiation,tissue type and maximum tumor diameter(P>0.05).The levels of serumβ-Klotho,FGF-19 and FGFR-4 had high auxiliary diagnostic efficacy in the diagnosis of thyroid cancer,the sensitivity of combined detection was 80.6%,the specificity was 97.2%,and the AUC was 0.944,which was significantly higher than that of the single detection ofβ-Klotho,FGF-19 and FGFR-4(Z=3.307,3.953,4.477,P<0.

关 键 词：β-Klotho 成纤维生长因子19 成纤维生长因子受体4 分化型甲状腺癌 

分 类 号：R736.1[医药卫生—肿瘤]