大肿瘤抑制激酶2基因多态性与原发性结直肠癌的关联性  

Associations of polymorphism in large tumor suppressor kinase 2 gene with colorectal cancer

作　　者：李迎泽 高芳[2] 卫星如 董文杰[1] 马立聪 党彤[3] 贾彦彬[1,3,4] Li Yingze;Gao Fang;Wei Xingru;Dong Wenjie;Ma Licong;Dang Tong;Jia Yanbin(Dept of Basic Medicine and Forensic Medicine,Baotou Medical College,Baotou 014060;College of Medical Technology and Anaesthesia,Baotou Medical College,Baotou 014060;Inner Mongolia Institute of Digestive Diseases,The Second Affiliated Hospital of Baotou Medical College,Baotou 014030;School of Nursing,Baotou Medical College,Baotou 014060)

机构地区：[1]包头医学院基础医学与法医学院,包头014060 [2]包头医学院医学技术与麻醉学院,包头014060 [3]包头医学院第二附属医院内蒙古消化病研究所,包头014030 [4]包头医学院护理学院,包头014060

出　　处：《安徽医科大学学报》2022年第12期1927-1932,共6页Acta Universitatis Medicinalis Anhui

基　　金：内蒙古自然科学基金(编号:2021LHMS08010,2020LH08004);包头医学院科学研究基金(编号:BYJJ-DF201603)。

摘　　要：目的探讨大肿瘤抑制激酶2(LATS2)基因单核苷酸多态性(SNP)rs558614、rs9552315、rs7317471和rs9509492与大肠癌发病风险的关联性。方法采用Taqman法将390例大肠癌患者和同期收集的413例正常对照进行基因分型,用非条件性Logistic回归计算比值比(OR)及其95%可信区间(CI),在共显性、显性、隐性、超显性和附加5种遗传模型下分别分析LATS2基因SNP rs558614、rs9552315、rs7317471和rs9509492与大肠癌、直肠癌和结肠癌发病风险的关联性;采用Haploview 4.2软件构建单体型。结果在共显性、显性、隐性、超显性和附加5种遗传模型下,SNP rs558614、rs9552315、rs7317471和rs9509492与大肠癌、直肠癌和结肠癌发病没有关联。4个SNP位点未能形成单体型块。结论LATS2基因SNP rs558614、rs9552315、rs7317471和rs9509492可能在大肠癌、直肠癌和结肠癌发病过程中不起主要作用。Objective To investigate the association between single nucleotide polymorphism(SNP)rs558614,rs9552315,rs7317471 and rs9509492 in large tumor suppressor kinase 2(LATS2)gene and the risk of colorectal cancer.Methods A total of 390 colorectal cancer patients and 413 healthy subjects were genotyped by Taqman method.The odds ratio(OR)and its 95%CI were calculated by unconditional logistic regression,to estimate the associations between SNP rs558614,rs9552315,rs7317471,rs9509492 in LATS2 gene and the risk of colorectal cancer,rectal cancer,as well as colon cancer under codominant,dominant,recessive,overdominant,and log-additive genetic models.Haplotypes were constructed by haploview software 4.2.Results SNP rs558614,rs7317471,rs9552315 and rs9509492 in LATS2 gene were not associated with the risk of colorectal cancer,rectal cancer and colon cancer under codominant,dominant,recessive,overdominant,and log-additive genetic models.No haploid blocks were formed between the 4 SNPs.Conclusion SNP rs558614,rs7317471,rs9552315,rs9509492 in LATS2 gene may not play a major role in the development of colorectal cancer,rectal cancer and colon cancer.

关 键 词：大肿瘤抑制激酶2 大肠癌 单核苷酸多态性 关联研究 

分 类 号：R394.5[医药卫生—医学遗传学]