VGLL4基因多态性与幽门螺杆菌感染的关系  

Association analysis between SNPs in VGLL4 gene and Helicobacter pylori infection

作　　者：杨霞 董文杰[1] 武金宝[2] 马立聪 孟宪梅[2] 高芳[3] 贾彦彬[1,2,4] Yang Xia;Dong Wenjie;Wu Jinbao;Ma Licong;Meng Xianmei;Gao Fang;Jia Yanbin(School of Basic Medicine and Forensic Medicine,Baotou Medical College,Baotou 014060;Inner Mongolia Institute of Digestive Diseases,The Second Affiliated Hospital of Baotou Medical College,Baotou 014030;School of Medical Technology and Anesthesiology,Baotou Medical College,Baotou 014060;School of Nursing,Baotou Medical College,Baotou 014060)

机构地区：[1]包头医学院基础医学与法医学院,包头014060 [2]包头医学院第二附属医院内蒙古消化病研究所,包头014030 [3]包头医学院医学技术与麻醉学院,包头014060 [4]包头医学院护理学院,包头014060

出　　处：《安徽医科大学学报》2023年第1期115-119,共5页Acta Universitatis Medicinalis Anhui

基　　金：国家自然科学基金(编号:81650017);内蒙古自然科学基金项目(编号:2020LH08004)。

摘　　要：目的探讨残留样蛋白质家族成员4(VGLL4)基因单核苷酸多态性(SNP)与幽门螺杆菌(H.pylori)感染的关系。方法选取450例体检者的血液样本,采用ELISA法将样本分为幽门螺杆菌阴性组(n=220)和幽门螺杆菌阳性组(n=230)。采用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)技术对VGLL4 SNP rs1803489、rs7617620、rs13078528位点进行基因分型。结果内蒙古包头地区汉族人群中VGLL4基因SNP rs1803489、rs7617620、rs13078528与幽门螺杆菌感染没有关联。结论在内蒙古包头地区的汉族人群中VGLL4基因SNP rs1803489、rs7617620、rs13078528在幽门螺杆菌感染中不起主要作用。Objective To investigate the associations between the single nucleotide polymorphism(SNP)in vestigial like family member 4(VGLL4)gene and Helicobacter pylori(H.pylori)infection.Methods The blood samples of 450 normal physical examiners were collected,and the samples were divided into H.pylori negative group(n=220)and H.pylori positive group(n=230)using enzyme-linked immunosorbent assay(ELISA).SNP rs1803489,rs7617620,and rs13078528 in VGLL4 gene were genotyped using polymerase chain reaction(PCR)-restriction fragment length polymorphism(RFLP)technology.Results SNP rs1803489,rs7617620,and rs13078528 in VGLL4 gene were not associated with H.pylori infection in the Han population in Baotou,Inner Mongolia.Conclusion SNP rs1803489,rs7617620,and rs13078528 in VGLL4 gene may not play a major role in H.pylori infection in Baotou Han population.

关 键 词：残留样蛋白质家族成员4 单核苷酸多态性 幽门螺杆菌 遗传易感性 

分 类 号：R394.5[医药卫生—医学遗传学]