单细胞转录组测序技术在炎症性肠病中的研究进展  

Progress of Research on Single-cell RNA Sequencing in Inflammatory Bowel Disease

作　　者：姚尧 王丹丹[1] 耿丽 张哲 冯百岁[1] 刘占举[2] YAO Yao;WANG Dandan;GENG Li;ZHANG Zhe;FENG Baisui;LIU Zhanju(Department of Gastroenterology,the Second Affiliated Hospital of Zhengzhou University,Zhengzhou,450014;Department of Gastroenterology,the Tenth People’s Hospital of Tongji University,Shanghai)

机构地区：[1]郑州大学第二附属医院消化内科,450014 [2]同济大学附属第十人民医院消化内科

出　　处：《胃肠病学》2021年第12期762-766,共5页Chinese Journal of Gastroenterology

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20190327,LHGJ20200396);河南省重点研发与推广专项(科技攻关)(212102310803);郑州大学前沿交叉研究专项项目(XKZDQY201906)。

摘　　要：炎症性肠病(IBD)为病因复杂的慢性非特异性肠道炎症,其具体的发病机制仍不完全清楚。随着高通量测序技术的不断更新和发展,其中基于单细胞水平的单细胞转录组测序技术的应用大大推进了对IBD发病机制、治疗等的认识。本文就近年单细胞转录组测序技术在IBD中的研究进展作一综述,以期为IBD发病机制的深入了解以及新药物的开发提供指导。Inflammatory bowel disease(IBD)is a chronic and nonspecific intestinal inflammation with complex etiology,and its pathogenesis is still not fully understood.With the continuous update and development of high-throughput sequencing technology,the application of single-cell RNA sequencing(scRNA-seq)based on single-cell level has greatly improved the knowledge of pathogenesis and treatment of IBD.This article reviewed the progress of research on scRNA-seq in study of IBD in recent years,so as to provide the guidance for in-depth understanding of mechanism of IBD and development of new therapeutic drugs.

关 键 词：炎症性肠病 单细胞转录组测序技术 肠上皮细胞 肠间质细胞 单核巨噬细胞 淋巴细胞 

分 类 号：R574[医药卫生—消化系统]