Extracellular Vesicles and Their Significance in COVID-19  

作　　者：Sanjay Kumar Soumi Sadhu Himanshu Narayan Singh Navneet Kumar Dubey Nikhil Kumar Prashant Kumar Tiwari Rajan Malhotra Himani Sharma 

机构地区：[1]Department of Life Science,School of Basic Science and Research,Sharda University,Greater Noida,UP,201310,India [2]Division of Nephrology,Mayo Clinic,Rochester,MN,55905,USA [3]Department of System Biology,Columbia University Irving Medical Center,New York,NY,10032,USA [4]Victory Biotechnology Co.,Ltd.,Taipei,Taiwan,114757,China [5]ShiNeo Technology Co.,Ltd.,New Taipei City,Taiwan,24262,China [6]Department of Medicine,All India Institute of Medical Sciences(AIIMS),New Delhi-110029,India

出　　处：《Advances in Human Physiology Research》2022年第1期1-4,共4页人体生理学研究进展（英文）

摘　　要：Over the last few years,there is huge scientific attention towards the research related to Extracellular Vesicles(EVs),because of their unique property of inter cellular communications and effective biological significance in diagnosis and therapy[1].Extracellular Vesicles are lipid bilayer membrane bound biological entity,which contains different bioactive compounds(cargoes)such as microRNAs(miRNAs),mRNAs,proteins,and lipids.Based on their origin and size,EVs have been categorized into three different types(a)Exosomes(40 nm-150 nm)are smallest EVs,which are synthesized by endocytic pathways in the cells and secreted in extracellular space through exocytosis process,(b)Microvesicles are secreted from direct budding off plasma membranes and their size varying from 50 nm to 1000 nm and,(c)Apoptotic bodies are formed during apoptotic cell death process and respectively larger in size>1000 nm[1-3].EVs have been identified using different markers,that includes tetraspanins proteins(CD9,CD63,CD81,and CD83),endosomal sorting complexes required for transport(TSG101,Alix),heat shock proteins(Hsp60,Hsp70,Hsp90),and Rab proteins(RAB27a/b)[1].

关 键 词：CD63 DIAGNOSIS CD81 

分 类 号：R73[医药卫生—肿瘤]