Polymorphism of Kdo-Based Glycolipids:The Elaborately Determined Stable and Dynamic Bicelles  

作　　者：Yingle Feng Long Li Qiqige Du Lu Gou Lei Zhang Yonghai Chai Ran Zhang Tongfei Shi Guosong Chen 

机构地区：[1]The State Key Laboratory of Molecular Engineering of Polymers,Department of Macromolecular Science,Fudan University,Shanghai 200433 [2]Key Laboratory of Applied Surface and Colloid Chemistry,Ministry of Education,School of Chemistry and Chemical Engineering,Shaanxi Normal University,Xi’an,Shaanxi 710119 [3]MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter,School of Science,Xi’an Jiaotong University,Xi’an 710049 [4]Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022 [5]Multiscale Research Institute of Complex Systems,Fudan University,Shanghai 200433

出　　处：《CCS Chemistry》2022年第7期2228-2238,共11页中国化学会会刊（英文）

基　　金：the financial support from the National Natural Science Foundation of China(grant nos.51721002,21861132012,91956127,and 21975047);NSFC/China(grant nos.21674114 and 91956127)for financial support;supported by the Shanghai Municipal Science and Technology Major Project(grant no.2018SHZDZX01)and ZJ Lab.

摘　　要：Understanding how the diversity of glycolipids,including how their chemical structures and composition affect their biological functions,is a remarkable fundamental challenge.In this work,we employed a rare monosaccharide,3-deoxy-Dmanno-2-octulosonic acid(Kdo)to build a simple and biomimetic model to understand the diversity of glycolipids from the viewpoint of supramolecular chemistry.Kdo was chosen not only because its unusual 8-carbon acidic carbohydrate backbone is very different from common hexoses,but also because of its key structural role in lipopolysaccharides and prevalence in bacteria,plant life,and algae.It was found that although both of the two Kdo-lipids S-Kdo and Kdo-S derived from the same carbohydrate backbone and gave bicelles as their self-assembled morphology,experimental results revealed that the self-assembly showed pathway complexity.Bicelle is the thermodynamic product of S-Kdo,while for Kdo-S,the bicelle is only a kinetically trapped state,which finally transforms to a ribbon.Molecular simulation clearly revealed the different packing of Kdo-lipids in the bicelles with different contribution from hydrogen bonds and electrostatic interactions.

关 键 词：GLYCOLIPID KDO SELF-ASSEMBLY BICELLES 

分 类 号：O6[理学—化学]