A Magnetocatalytic Propelled Cobalt-Platinum@Graphene Navigator for Enhanced Tumor Penetration and Theranostics  

作　　者：Liang Zhang Qian Dong Hui Zhang Jieqiong Xu Shen Wang Lufeng Zhang Wentao Tang Zhaoqian Li Xin Xia Xinqi Cai Shengkai Li Ruizi Peng Zhengyu Deng Michael JDonovan Long Chen Zhuo Chen Weihong Tan 

机构地区：[1]Molecular Science and Biomedicine Laboratory(MBL),State Key Laboratory of Chemo/Biosensing and Chemometrics,College of Chemistry and Chemical Engineering,College of Biology,Aptamer Engineering Center of Hunan Province,Hunan University,Changsha,Hunan 410082 [2]Faculty of Science and Technology,University of Macao,Taipa,Macao 999078 [3]The Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital),Institute of Basic Medicine and Cancer(IBMC),Chinese Academy of Sciences,Hangzhou,Zhejiang 310022

出　　处：《CCS Chemistry》2022年第7期2382-2395,共14页中国化学会会刊（英文）

基　　金：financially supported by the National Natural Science Foundation of China(grant no.21522501);Hunan Provincial Natural Science Foundation of China(grant no.2020RC4017);National Postdoctoral Program for Innovative Talents of China(grant no.BX20190111);the Science and Technology Development Fund,Macao(no.196/2017/A3).

摘　　要：Complex biological environments and multiple physiological barriers significantly impede efficient accumulation and penetration of nanomaterials within tumor tissue for therapy.In situ energy conversion of nanomotors features autonomous movements and improves cancer treatment.However,one of the key challenges is to prepare nanomotors with an adequately small size,good biocompatibility,and precise positioning.Herein,we demonstrate a simple,ultrasmall,versatile,and real-time motion guidance strategy for magnetocatalytic CoPt@graphene navigators(MCGNs)that can enable highly efficient propulsion in the presence of H_(2)O_(2) or magnetic actuation.MCGNs act as highly diffusive delivery vehicles to promote tumor tissue targeting,and the amount of drug in the tumor was three times than without navigation.By engaging movements powered through in situ energy conversion,MCGNs gain considerable propulsion to penetrate a cell’s membrane and enhance intracellular delivery.

关 键 词：magnetocatalytic propelled nanomotors NAVIGATOR tumor penetration photothermal therapy tumor theranostics 

分 类 号：R730.5[医药卫生—肿瘤]