肠道菌群失调及其介导的炎症反应在失血性休克发展进程中的作用  

Roles of gut microflora dysbiosis and related inflammation in development of hemorrhagic shock

作　　者：陈斯洁 赵振奥 赵自刚[1,2] 牛春雨[1,2] CHEN Sijie;ZHAO Zhen'ao;ZHAO Zigang;NIU Chunyu(Institute of Microcirculation,Basic Medical College,Hebei North University,Zhangjiakou 075000,China;Hebei Key Laboratory of Critical Disease Mechanism and Intervention,Zhangjiakou 075000,China)

机构地区：[1]河北北方学院微循环研究所/基础医学院,河北张家口075000 [2]河北北方学院河北省急危重症发病机制及干预重点实验室,河北张家口075000

出　　处：《中国病理生理杂志》2023年第1期186-192,共7页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.81770492)。

摘　　要：严重创伤患者早期的死亡率高达30%~40%,失血性休克是严重创伤患者死亡的主要原因之一。失血性休克早期,由于有效循环血量减少、交感神经兴奋,引起的血液重新分布,导致腹腔脏器的血管收缩,肾脏、肝脏、肠道低灌注,持续缺血缺氧引起主要器官发生缺血性损伤[1]。其中,肠道在失血性休克引起多器官功能障碍、结构损伤发展进程中的关键作用受到越来越多的关注[2]。肠道微生物群平衡对维持肠道内环境平衡和人类健康至关重要。Gut microflora dysbiosis plays an important role in hemorrhagic shock. Hemorrhagic shock induces gut microflora dysregulation which is characterized by increased Proteobacteria and decreased Bacteroidetes, and further induces a series of changes in bacterial metabolites. Gut microbiota dysregulation and metabolites are involved in intestinal injury and intestinal barrier damage through inflammation. The inflammatory factors enter into mesenteric lymphatics and are transported into systemic circulation, inducing multiple organ dysfunction. Therefore, this article reviews gut microbiota dysregulation and the related inflammation in hemorrhagic shock. This review revealed the relationship among gut microbiota, intestinal lymphatic pathway, and uncontrolled inflammation, to provide a novel insight for prevention and treatment of severe hemorrhagic shock.

关 键 词：肠道菌群 细菌代谢物 炎症 失血性休克 肠淋巴液 

分 类 号：R574.4[医药卫生—消化系统] R364.5[医药卫生—内科学]