Detection of angiospastic disorders in the microcirculatory bed using laser diagnostics technologies  

作　　者：Irina N.Makovik Andrey V.Dunaev Victor V.Dremin Alexander I.Krupatkin Viktor V.Sidorov Lyudmila S.Khakhicheva Vadim F.Muradyan Olga V.Pilipenko Ilya E.Rafailov Karina S.Litvinova 

机构地区：[1]Biomedical Photonics Instrumentation Group Scientic-Educational Centre of"Biomedical Engineering"Orel State University named after I.S.Turgenev Orel 302026,Russian Federation [2]Priorov Central Research Institute of Traumatology and Orthopaedics Moscow 127299,Russian Federation [3]SPE"LAZMA"Ltd,Moscow 125252,Russian Federation [4]Orel Regional Clinical Hospital Orel 302028,Russian Federation [5]School of Engineering and Applied Sciences Aston Institute of Photonic Technologies Aston University,Birmingham,B47ET,UK [6]Optoelectronics and Biomedical Photonics Group Aston Institute of Photonic Technologies Aston University,Birmingham,B47ET,UK [7]Aston Medical School Aston University,Birmingham,B47ET,UK

出　　处：《Journal of Innovative Optical Health Sciences》2018年第1期65-79,共15页创新光学健康科学杂志（英文）

摘　　要：The evaluation of the microcirculatory bed functional state and the identification of angiospastic disorders with related complications,when the pathological changes are reversible,have an important role in medical practice.The aim of this study was to evaluate the possibility of using optical noninvasive methods and the cold pressor test to solve this problem.A total of 33 patients with rheumatological diseases and 32 healthy volunteers were included in the study.Laser Doppler flowmetry,tissue reflectance oximetry and pulse oximetry were used as optical noninvasive methods.The parameters were recorded before,immediately after and 20 min after the cold pressor test.Based on the measured parameters,the complex parameters of the microcirculatory bed were calculated.A detailed statistical analysis of the parameter changes for each individual in the two groups displayed diverse microcirculatory bed parameter responses upon cold exposure,with differing recovery of parameters after CPT.New diagnostic criteria were proposed for the identification of angiospastic disorders.According to the proposed criteria,27 people of the volunteers group were confirmed to not display any disorders.In the patient group,however,18 people were observed to have a relatively normal functional state of the microcirculatory bed,while 15 people were observed to have a possible tendency to angiospasm.To highlight the diferences between a relatively normal state and presence of angiospastic disorders,statistical analysis of experimental data was carried out,which revealed significant differences.Further analysis of data with angiospastic disorders identified a relationship between their diagnoses and the results of labo-ratory studies.Thus,the evaluation of combined noninvasive optical diagnostic method use,the cold pressor test and proposed diagnostic criteria showed a positive result.This approach can be used to detect the presence of possible angiospastic disorders and related complications,as well as mi-crocirculatory bed disorders against

关 键 词：Noninvasive diagnostics laser Doppler flowmetry tissue relctance oximetry pulse oximetry cold pressor test microcirculatory bed angiospasm 

分 类 号：R57[医药卫生—消化系统]