静脉滴注榄香烯联合腹腔热灌注化疗治疗胃癌腹腔转移的效果  

Efficacy observation of intravenous infusion of elemene combined with hyperthermic intraperitoneal chemotherapy for the gastric cancer with intraperitoneal metastasis

作　　者：黄永红 萧嘉铭 刘美媛 HUANG Yong-hong;XIAO Jia-ming;LIU Mei-yuan(Department of Gastrointestinal Surgery,Affiliated Cancer Hospital&Institute of Guangzhou Medical University,Guangzhou(510095),China)

机构地区：[1]广州医科大学附属肿瘤医院胃肠外科二区,广州510095 [2]广州医科大学附属肿瘤医院内三科,广州510095

出　　处：《中国中西医结合外科杂志》2023年第1期55-60,共6页Chinese Journal of Surgery of Integrated Traditional and Western Medicine

基　　金：广东省中医药局项目(20221253)。

摘　　要：目的:探讨静脉滴注榄香烯联合腹腔热灌注化疗(HIPEC)对胃癌腹腔转移患者的临床疗效。方法:回顾性分析2017年1月—2019年12月我院收治的108例因胃癌腹腔转移进行HIPEC治疗患者的临床资料,对照组58例,单纯采用HIPEC治疗;观察组50例,采用静脉滴注榄香烯联合HIPEC治疗。治疗结束后4周,评价两组患者的免疫相关指标、肿瘤标志物、不良反应、短期疗效及随访生存期的情况。结果:治疗后,两组患者CD3^(+)、CD4^(+)和CD4^(+)/CD8+比例较治疗前均明显上升,其中观察组均显著高于对照组(P<0.05);治疗后,两组肿瘤标志物癌胚抗原(CEA)、CA199、CA125的表达水平均有不同程度下降,其中观察组CA199、CA125显著低于对照组(P<0.05);两组腹胀腹痛和恶心呕吐的发生率差异无统计学意义(P>0.05),观察组的骨髓抑制、肝功能损害和肾功能损害发生率均显著低于对照组(P<0.05);两组临床疗效比较,观察组的短期总缓解率显著优于对照组(P<0.05),但两组患者的短期疾病控制率比较差异无统计学意义(P>0.05),随访发现观察组的生存期明显高于对照组(P<0.05)。结论:HIPEC治疗可以明显提高胃癌腹腔转移患者的生存期,辅助静脉滴注中药榄香烯可以更好改善患者的免疫功能,减轻HIPEC治疗的不良作用,提高短期疗效以及延长生存期。Objective To investigate the clinical efficacy of intravenous infusion of elemene combined with hyperthermic intraperitoneal chemotherapy(HIPEC)in patients with gastric cancer with intraperitoneal metastasis.Methods The clinical data of 108 patients with gastric cancer intraperitoneal metastasis who received HIPEC treatment from January 2017 to December 2019 were retrospectively analyzed.The control group consisted of 58 patients treated with HIPEC alone,and the observation group consisted of 50 patients treated with intravenous infusion of elemene combined with HIPEC.Four weeks after the end of treatment,the immune cells,tumor markers,adverse reactions,short-term efficacy and follow-up survival of the two groups were evaluated.Results After treatment,the ratios of CD3^(+),CD 4^(+)and CD 4^(+)/CD 8^(+)in the two groups were significantly increased compared with those before treatment,and the ratios in the observation group were significantly higher than those in the control group(P<0.05).After treatment,the expression levels of tumor markers CEA,CA199and CA125 in the two groups decreased,and CA199 and CA125 in the observation group were significantly lower than those in the control group(P<0.05).Compared the adverse reactions between the two groups,there was no significant difference in the incidence of abdominal distension,abdominal pain and nausea and vomiting(P>0.05);the incidence of bone marrow suppression,liver function damage and renal function damage in the observation group were significantly lower than those in the control group(P<0.05).Compared the clinical efficacy between the two groups,the short-term overall response rate of the observation group was significantly better than that of the control group(P<0.05),but there was no significant difference in the short-term disease control rate between the two groups(P>0.05).The follow-up results showed that the survival time of the observation group was significantly higher than that of the control group(P<0.05).Conclusion HIPEC can significantly improve th

关 键 词：榄香烯 腹腔热灌注化疗 胃癌腹腔转移 临床疗效 

分 类 号：R735.2[医药卫生—肿瘤]