健脾定抽颗粒辅助治疗儿童多发性抽动症脾虚痰聚证31例临床观察  

Clinical observation on 31 cases of Tourette syndrome in children with spleen deficiency and phlegm accumulation syndrome treated by Jianpi Dingchou Keli(健脾定抽颗粒) as adjuvant therapy

作　　者：李亚群[1] 严伟[2] 竺永昌 田云龙 王靖[1] 王爱珍[1] LI Yaqun;YAN Wei;ZHU Yongchang;TIAN Yunlong;WANG Jing;WANG Aizhen(Pediatrics,Taizhou Hospital of Traditional Chinese Medicine,Taizhou,Jiangsu,225300,China;Pediatrics,Jiangyin Hospital of Traditional Chinese Medicine,Jiangyin,Jiangsu,214400,China)

机构地区：[1]泰州市中医院儿科,江苏泰州225300 [2]江阴市中医院儿科,江苏江阴214400

出　　处：《中医儿科杂志》2022年第6期53-57,共5页Journal of Pediatrics of Traditional Chinese Medicine

基　　金：江苏省中医药科技发展计划项目(YB201978);第三批江苏省名老中医药专家传承王靖工作室建设项目(苏中医科教[2019]10号)。

摘　　要：目的观察健脾定抽颗粒辅助治疗儿童多发性抽动症(TS)脾虚痰聚证的临床疗效。方法选取2019年10月至2020年10月在泰州市中医院儿科就诊的TS脾虚痰聚证患儿72例,采用随机数字表法分为治疗组和对照组,各36例,其中治疗组脱落5例,对照组脱落6例,最终治疗组31例,对照组30例。所有患儿均予针刺加经颅微电流刺激仪作为基础治疗,治疗组在基础治疗的基础上加健脾定抽颗粒治疗,对照组在基础治疗的基础上加盐酸硫必利片治疗,2组均治疗12周后统计临床疗效,比较治疗前后耶鲁综合抽动症严重程度量表(YGTSS)评分和中医证候积分。结果治疗组总有效率为83.87%(26/31),对照组为86.66%(26/30),2组总有效率比较,差异无统计学意义(P>0.05)。治疗前,2组YGTSS评分、运动性抽动积分、发声性抽动积分、中医证候积分比较,差异均无统计学意义(P>0.05),具有可比性;治疗后,2组YGTSS评分、运动性抽动积分、发声性抽动积分、中医证候积分均显著下降,与同组治疗前比较,差异有统计学意义(P<0.01),且治疗组中医证候积分下降更显著(P<0.01)。2组患儿治疗前后心电图、肝肾功能均无异常,未见明显不良反应。结论健脾定抽颗粒辅助治疗儿童TS脾虚痰聚证可显著改善中医证候积分,安全性良好,疗效满意,值得临床推广应用。Objective To observe the clinical efficacy of Jianpi Dingchou Keli(健脾定抽颗粒)in adjuvant treatment of Tourette syndrome(TS)in children with spleen deficiency and phlegm accumulation.Methods From October 2019 to October 2020,72 cases of TS in children with spleen deficiency and phlegm accumulation syndrome admitted into Pediatrics Department of Taizhou Hospital of Traditional Chinese Medicine were chosen and divided into treatment group and control group using a random number table,with 36 cases in each group.There were 5 drop-out cases and 31 cases of actual completion in the treatment group;6 drop-out cases and 30 cases of actual completion in the control group.All children were treated by acupuncture and transcranial microcurrent stimulator as the basic treatment.The treatment group was treated by Jianpi Dingchou Keli on the basis of basic treatment,and the control group was treated by tiapride hydrochloride tablets on the basis of basic treatment.We kept statistics,made comparison and contrast about the clinical efficacy,the Yale Global Tic Severity Scale(YGTSS)score,motor tic score,vocal tic score and TCM syndrome score of the two groups before and after 12-week treatment.Results The total effective rate was 86.66%(26/31)in the treatment group and 83.87%(26/30)in the control group.There was no significant difference in the total effective rate between the two groups(P>0.05).Before treatment,there was no significant difference being found in the comparison of YGTSS score,motor tic score,vocal tic score and TCM syndrome score between the two groups(P>0.05),which were comparable;after treatment,the YGTSS score,motor tic score,vocal tic score,and TCM syndrome score were decreased significantly in the same group,the difference was statistically significant(P<0.01),and the decrease in the treatment group was more significant(P<0.01).There were no abnormalities in electrocardiogram,liver and kidney function before and after treatment in the two groups,and no obvious adverse reactions were observed.Conclusio

关 键 词：多发性抽动症 儿童 脾虚痰聚证 健脾定抽颗粒 临床观察 

分 类 号：R749.94[医药卫生—神经病学与精神病学]