Diversity-Oriented Enantioselective Construction of Atropisomeric Heterobiaryls and N-Aryl Indoles via Vinylidene Ortho-Quinone Methides  

作　　者：Da Xu Shengli Huang Fangli Hu Lei Peng Shiqi Jia Hui Mao Xiangnan Gong Fenglan Li Wenling Qin Hailong Yan 

机构地区：[1]Chongqing Key Laboratory of Natural Product Synthesis and Drug Research,School of Pharmaceutical Sciences,Chongqing University,Chongqing 401331 [2]College of Pharmacy,Jinhua Polytechnic,Jinhua,Zhejiang Province 321007 [3]Analytical and Testing Center of Chongqing University,Chongqing University,Chongqing 401331 [4]Anqiu Women and Children’s Hospital,Anqiu,Shandong Province 262102

出　　处：《CCS Chemistry》2022年第8期2686-2697,共12页中国化学会会刊（英文）

基　　金：provided by the Zhejiang Provincial Natural Science Foundation of China(grant no.LQ19B020003);the Scientific Research Foundation of China(grant nos.21922101,21772018,and 21901026);the Fundamental Research Funds for the Central Universities(project no.2020CQJQY-Z002).

摘　　要：An atroposelectively diversity-oriented synthetic strategy was developed for the divergent synthesis of axially chiral heterocycles through organocatalytic asymmetric intramolecular annulation of alkyne via vinylidene ortho-quinone methides(VQMs).The methodology reported herein was characterized by rapid reactions(most completed in seconds),high stereocontrol(up to 98%ee),and broad substrate scope(60 examples of different skeletal types,stereogenicelements,andring sizes).

关 键 词：asymmetric catalysis ORGANOCATALYSIS atroposelectivity axial chirality HETEROANNULATION 

分 类 号：O62[理学—有机化学]