Exploring Sequence Space to Design Controllable G-Quadruplex Topology Switches  

作　　者：Jielin Chen Mingpan Cheng Petr Stadlbauer JiříŠponer Jean-Louis Mergny Huangxian Ju Jun Zhou 

机构地区：[1]State Key Laboratory of Analytical Chemistry for Life Science,School of Chemistry and Chemical Engineering,Nanjing University,Nanjing 210023 [2]Institute of Biophysics of the Czech Academy of Sciences,Královopolská135,Brno 61265 [3]Regional Centre of Advanced Technologies and Materials,Czech Advanced Technology and Research Institute(CATRIN),Palacky University Olomouc,Šlechtitelů241/27,Olomouc–Holice 78371 [4]Laboratoire d’Optique et Biosciences,Ecole Polytechnique,CNRS,INSERM,Institut Polytechnique de Paris,Palaiseau 91128

出　　处：《CCS Chemistry》2022年第9期3036-3050,共15页中国化学会会刊（英文）

基　　金：supported in part by the National Natural Science Foundation of China(nos.21977045 and 21635005);the Fundamental Research Funds for the Central Universities(no.02051430210);the funds of Nanjing University(no.020514912216);project 21-23718S of the Czech Science Foundation(P.S.and J.S.);the project SYMBIT reg.number:CZ.02.1.01/0.0/0.0/15_003/0000477 financed by the ERDF(J.S.and J.-L.M.).

摘　　要：As nonclassical nucleic acid structures,G-quadruplexes(G4s)not only play important roles in gene regulation and stability maintenance,but are also widely used in nanotechnology.Structural diversity is one of the main factors explaining the popularity of G4s,but a comprehensive and integrated study of different factors determining G4 structural versatility is currently lacking.

关 键 词：G-QUADRUPLEX G-quadruplex topology Gswitch sequence composition structural versatility 

分 类 号：O65[理学—分析化学]