遗传修饰猪模型在生物医学及农业领域研究进展及应用  

Advances and applications of genetically modified pig models in biomedical and agricultural field

作　　者：高菲 王煜 杜嘉祥 杜旭光 赵建国[2] 潘登科 吴森 赵要风[1] Fei Gao;Yu Wang;Jiaxiang Du;Xuguang Du;Jianguo Zhao;Dengke Pan;Sen Wu;Yaofeng Zhao(State Key Laboratory of Agrobiotechnology,College of Biological Sciences,China Agricultural University,Beijing 100193,China;Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China;Chengdu Clonorgan Biotechnology Co.,Ltd,Chengdu 610000,China;Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province,Sichuan Academy of Medical Sciences&Sichuan Provincial People’s Hospital,Chengdu 610072,China)

机构地区：[1]中国农业大学生物学院,农业生物技术国家重点实验室,北京100193 [2]中国科学院动物研究所,北京100101 [3]成都中科奥格生物科技有限公司,成都610000 [4]四川省医学科学院四川省人民医院,临床免疫转化医学四川省重点实验室,成都610072

出　　处：《遗传》2023年第1期6-28,共23页Hereditas（Beijing)

基　　金：国家重点研发计划(编号:2021YFA0805900);海南省崖州湾种子实验室“揭榜挂帅”项目(编号:B21HJ0103)资助。

摘　　要：猪在解剖结构、代谢、生理生化等特征方面比啮齿类动物更接近人类,因此在模拟某些人类疾病以及提供异种移植器官等方面具有其他动物不可替代的优势,是理想的人类疾病动物模型和异种器官的供体。另外,猪作为我国畜牧业最重要的物种之一,猪的品种改良、疫病防控以及动物福利等问题都与人民生活息息相关。本文主要介绍了遗传修饰猪模型在分子育种、人类疾病模型以及异种器官移植领域的研究进展及未来应用前景,希望增进相关领域研究人员对基因编辑等前沿技术的了解,理解遗传修饰猪模型在生命科学研究中的重要意义。Compared with rodents,pigs are closer to humans in terms of anatomy,metabolism and physiology,so they are ideal animal models of human diseases and xenotransplantation donors.In addition,as one of the most important livestock in China,pigs are closely related to our lives in terms of breeding improvement,disease prevention and animal welfare.In this review,we mainly summarize the research progress and future application of genetically modified pig models in the fields of xenotransplantation,molecular breeding and human disease models.We wish to take this opportunity to raise the awareness of researchers in related fields on cutting-edge technologies such as gene editing and understand the significance of genetically modified pig models in life science research.

关 键 词：遗传修饰猪 分子育种 疾病模型 异种器官移植 

分 类 号：R-332[医药卫生]