CDKN2A/2B基因rs10811661多态性对2型糖尿病患者糖化血红蛋白水平的影响分析  

CDKN2A/2B gene polymorphism rs10811661 affects the level of glycosylated hemoglobin in patients with type 2 diabetes

作　　者：齐科研[1] 杨锴 万钢 冯洁[3] 孙飞 王一鹏[1] QI Keyan;YANG Kai;WAN Gang;FENG Jie;SUN Fei;WANG Yipeng(Prenatal Diagnosis Center of Beijing Maternal and Child Health Care Hospital,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing 100026,China;Beijing Ditan Hospital,Capital Medical University,Beijing 100102,China;Department of Neurosurgery,Beijing Tiantan Hospital,Capital Medical University,Beijing 100050,China;Cuigezhuang Community Health Service Center,Chaoyang District,Beijing 100015,China)

机构地区：[1]首都医科大学附属北京妇产医院/北京妇幼保健院产前诊断中心,北京100026 [2]首都医科大学附属北京地坛医院,北京100102 [3]首都医科大学附属北京天坛医院神经外科研究所,北京100050 [4]北京市朝阳区崔各庄社区卫生服务中心,北京100015

出　　处：《中国优生与遗传杂志》2022年第11期1985-1988,共4页Chinese Journal of Birth Health & Heredity

摘　　要：目的 探讨CDKN2A/2B基因多态性对2型糖尿病患者糖化血红蛋白水平的影响。方法 以370例社区2型糖尿病患者为研究对象,调查患者的一般情况、血压、血糖、血脂等生理生化结果;并对每位患者采2 mL的静脉血,提取DNA,并应用PCR-RFLP法检测CDKN2A/2B基因rs10811661位点的多态性。结果 CDKN2A/2B基因rs10811661多态位点,C等位基因频率为47.43%;不同糖化水平两组患者的基因型、等位基因的分布差异无统计学意义(P>0.05);CT基因型与CC+TT基因型糖尿病患者的性别、教育水平、保险类型、服用降糖药治疗、血糖监测频率的构成,差异无统计学意义(P>0.05);CC+TT基因型糖尿病患者的HbA1c总体均值水平为7.17%±1.45%,CT基因型糖尿病患者的HbA1c总体均值水平为6.89%±1.13%,两组差异有统计学意义(P=0.04)。结论 CDKN2A/2B基因rs10811661位点的多态性影响2型糖尿病患者糖化血红蛋白水平,糖尿病患者的血糖管理不仅要注重环境因素,同时也要注重个体遗传因素的影响。Objective To investigate how the CDKN2A/2B gene polymorphism rs10811661 affects the level of glycated hemoglobin in patients with type 2 diabetes. Methods 370 cases of type 2 diabetes from community were enrolled in this study. We investigated the patient’s general condition, blood pressure, blood glucose, lipids, and collected 2 mL of venous blood from each patient. Then the DNA was extracted, and the PCR-RFLP method was applied to detect the rs10811661polymorphism of CDKN2A/2B gene. Results In terms of the CDKN2A/2B gene rs10811661 polymorphism of our cohort, the C allele frequency was 47.43%. The difference of allele distribution between the two groups of patients with various glycated hemoglobin levels was not significant(P>0.05). The differences in gender, educational level, type of insurance, taking hypoglycemic agents or not, and blood glucose monitoring frequency in the patients with CT and CC+TT genotypes were not statistically significant(P>0.05). The mean level of HbA1c in patients with CC+TT phenotypes was 7.17%±1.45%, and that of CT genotype was 6.89%±1.13%, and the difference of these two groups was statistically significant(P=0.04). Conclusion The CDKN2A/2B gene rs10811661 polymorphism affected the level of glycated hemoglobin in type 2 diabetes. So diabetics blood sugar management is not the only key factors, and we also should pay attention to the individual genetic background.

关 键 词：2型糖尿病 CDKN2A/2B基因 基因多态性 血糖 

分 类 号：R587.1[医药卫生—内分泌]