卵巢癌患者癌组织中CDCA5表达与临床病理特征及预后的关系  

Relationship between the expression of CDCA5 in ovarian cancer and clinicopathological features and prognosis

作　　者：龚姗[1] 李苗[1] 白波 付静静[3] 韩琨 姜丽[1] 金海红[1] GONG Shan;LI Miao;BAI Bo;FU Jingjing;HAN Kun;JIANG Li;JIN Haihong(Department of Gynecology,First Hospital of Qinhuangdao,Qinhuangdao,Hebei 066000,China;Department of Orthopaedics,First Hospital of Qinhuangdao,Qinhuangdao,Hebei 066000,China;Department of Hospital Infection-Control,First Hospital of Qinhuangdao,Qinhuangdao,Hebei 066000,China)

机构地区：[1]秦皇岛市第一医院妇科,河北秦皇岛066000 [2]秦皇岛市第一医院骨科,河北秦皇岛066000 [3]秦皇岛市第一医院院感科,河北秦皇岛066000

出　　处：《中国优生与遗传杂志》2022年第11期1989-1994,共6页Chinese Journal of Birth Health & Heredity

基　　金：秦皇岛市科技计划项目(202101A066)。

摘　　要：目的探究卵巢癌患者癌组织中细胞分裂周期相关蛋白5(CDCA5)表达与临床病理特征及预后的关系。方法选择2017年1月至2019年3月于秦皇岛市第一医院进行手术治疗的178例卵巢癌患者为研究对象,检测癌组织及正常卵巢组织中CDCA5的表达情况;根据CDCA5的表达水平,将患者分为高表达组(n=91)和低表达组(n=87),探讨CDCA5表达水平与病理特征的关系;对患者随访3年,依据复发情况将患者分为复发组(n=83)和未复发组(n=95),探究患者术后复发的影响因素,并构建预测模型。通过采用KaplanMeier生存曲线分析不同CDCA5的表达水平的患者的复发率。结果CDCA5在卵巢癌组织中表达量显著高于正常卵巢组织。CDCA5表达水平与肿瘤直径、FIGO分期、肿瘤分化程度及淋巴结转移之间存在密切联系(P<0.05)。与未复发组相比,复发组患者年龄较大、肿瘤直径较大、肿瘤数目较多、CA125水平较高、CDCA5表达水平较高、淋巴结转移和腹腔积液发生较多、FIGO分期主要为Ⅲ~Ⅳ期、肿瘤分化程度主要为低分化、肿瘤浸润深度主要为T3+T4。多因素Logistic回归分析结果显示,肿瘤大小≥5 mm、FIGO分期Ⅲ~Ⅳ、肿瘤低分化、淋巴结转移、CDCA5高表达是卵巢癌患者术后复发的独立危险因素(P<0.05)。Kaplan Meier生存曲线显示CDCA5高表达的患者3年复发率较CDCA5低表达的患者高(P<0.05)。结论CDCA5在卵巢癌组织中表达量明显增高,与卵巢癌的肿瘤直径、FIGO分期、肿瘤分化程度及淋巴结转移之间存在密切联系。CDCA5高表达是卵巢癌患者术后复发的独立危险因素,可能提示患者预后不良。Objective To explore the relationship between the expression of cell division cycle associated protein 5(CDCA5)and clinicopathological features and prognosis in patients with ovarian cancer.Methods 178 patients with ovarian cancer who underwent surgery in First Hospital of Qinhuangdao from January 2017 to March 2019 were selected as the research objects,and their cancer tissues and normal ovarian tissues were stained.The expression of CDCA5 in tissues was detected.According to the expression level of CDCA5,the patients were divided into high expression group(n=91)and low expression group(n=87).The patients were followed up for 3 years and the prognosis was counted.According to the recurrence,the patients were divided into recurrence group(n=83)and non recurrence group(n=95).The influencing factors of postoperative recurrence were explored and the prediction model was constructed.The recurrence rate of patients with different expression levels of CDCA5 was analyzed by Kaplan Meier survival curve.Results The expression of CDCA5 in ovarian cancer tissues was significantly higher than that in normal ovarian tissues.The expression level of CDCA5 was closely related to tumor diameter,FIGO stage,tumor differentiation and lymph node metastasis(P<0.05).Compared with the non recurrence group,the patients in the recurrence group were older(P<0.05),larger tumor diameter(P<0.05),more tumor number(P<0.05),higher CA125 level(P<0.05),lower expression level of CDCA5(P<0.05),more lymph node metastasis and peritoneal effusion(P<0.05),FIGO stage was mainly stageⅢ–Ⅳ(P<0.05),tumor differentiation was mainly poorly differentiated(P<0.05),the depth of tumor invasion was mainly T3+T4(P<0.05).Multivariate logistic regression analysis showed that tumor size≥5 mm,FIGO stageⅢ–Ⅳ,low tumor differentiation,lymph node metastasis and high expression of CDCA5 were independent risk factors for postoperative recurrence of ovarian cancer patients(P<0.05).Kaplan Meier survival curve showed that the 3-year recurrence rate of patients with

关 键 词：卵巢癌 细胞分裂周期相关蛋白5 临床病理特征 预后 预测模型 

分 类 号：R737.31[医药卫生—肿瘤]