ω-3鱼油脂肪乳剂对重症胰腺炎患者腹内高压及肠黏膜功能的影响  

Effects of omega-3 fish oil lipid emulsion on intra-abdominal hypertension and intestinal mucosal function in patients with severe pancreatitis

作　　者：马晓惠 单艳华 李小霞 王喜梅 MA Xiao-hui;SHAN Yan-hua;LI Xiao-xia;WANG Xi-mei(Department of Critical Medicine,Zhumadian Central Hospital,Zhumadian 463000,China)

机构地区：[1]驻马店市中心医院重症医学科,驻马店463000

出　　处：《天津医科大学学报》2023年第1期73-77,共5页Journal of Tianjin Medical University

摘　　要：目的:探讨ω-3鱼油脂肪乳剂对重症胰腺炎患者腹内高压及肠黏膜功能的影响。方法:选择驻马店市中心医院重症医学科收治的136例重症胰腺炎患者作为研究对象,进行前瞻性研究,并按照随机数字表法分为对照组和观察组,各68例。其中对照组给予常规治疗法进行治疗,观察组在上述治疗的基础上外加ω-3鱼油脂肪乳剂进行治疗。观察两组患者治疗后病情缓解时间变化,比较两组患者治疗前后肠黏膜功能指标、趋化因子及腹内压水平变化,分析两组患者治疗效果差异。结果:观察组腹痛缓解时间、腹胀缓解时间、肠鸣音恢复时间以及肛门首次排便时间等病情症状明显改善(均P<0.05)。与治疗前相比,两组治疗后的血清肠型脂肪酸结合蛋白(I-FABP)、二胺氧化酶(DAO)、D-乳酸、中性粒细胞趋化因子(CINC)、FKN、单核细胞趋化因子蛋白-1(MCP-1)及乳果糖/甘露醇(L/M)、腹内压水平明显低于对照组,血清三叶因子(ITF)、乳脂球表皮生长因子8(MFG-E8)明显降低,且观察组改善更显著(均P<0.05)。观察组患者治疗有效率为94.12%,明显高于对照组的76.47%(P<0.05)。结论:ω-3鱼油脂肪乳剂治疗重症胰腺炎患者,可以有效缓解其临床症状,改善腹内高压及肠黏膜功能,增强疗效,具有一定临床参考价值。O bjective:To explore the effect of omega-3 fish oil fat emulsion on intra-abdominal hypertension and intestinal mucosal function in patients with severe acute pancreatitis. Methods:A total of 136 patients with severe pancreatitis admitted to the Department of Critical Care Medicine of Zhumadian Central Hospital were selected as the research objects for prospective study,and they were divided into the control group and the observation group according to the random number table method,with 68 cases in each group. The control group was treated with conventional therapy,and the observation group was additionally treated with omega-3 fish oil fat emulsion on the basis of the above treatment. The changes in the remission time of patients of the two groups after treatment were observed,the changes of intestinal mucosal function indexes,chemokines and intra-abdominal pressure levels were compared between the two groups before and after treatment,and the differences in the treatment effects of the two groups were analyzed. Results:The symptoms of abdominal pain relief,abdominal distension relief time,bowel sound recovery time and anal first defecation time were significantly proved in the observation group,and the difference was statistically significant(all P<0.05).Compared with before treatment,the levels of serum intestinal fatty acid binding protein(I-FABP),diamine oxidase(DAO),D-lactic acid,neutrophil chemokine(CINC),FKN,monocyte chemokine protein-1(MCP-1),lactulose/mannitol(L/M)and intra-abdominal pressure of the two groups were significantly lower than those of the control group,serum trefoil factor(ITF)and lactoglobular epidermal growth factor 8(MFG-E8)were significantly higher than those of the control group,and the above indicators were significantly improved in the observation group(all P<0.05).The effective rate of treatment in the observation group was 94.12%,which was significantly higher than that in the control group(76.47%). The difference was statistically significant(P<0.05). Conclusion:Omega-3 fish oi

关 键 词：Ω-3鱼油脂肪乳剂 重症胰腺炎 腹内高压 肠黏膜功能 

分 类 号：R781.4[医药卫生—口腔医学]