非小细胞肺癌脑转移研究进展  

Research advances in brain metastasis of non-small cell lung cancer

作　　者：马力 朱娅[1] 王朝霞[1] MA Li;ZHU Ya;WANG Zhaoxia(Oncology Medical Center,the Second Affiliated Hospital of Nanjing Medical University,Jiangsu Province,Nanjing210011,China)

机构地区：[1]南京医科大学第二附属医院肿瘤医学中心,江苏南京210011

出　　处：《中国医药导报》2023年第3期37-40,54,共5页China Medical Herald

基　　金：国家自然科学基金资助项目(82072591)。

摘　　要：肺癌是常见的高发病率、高死亡率的恶性肿瘤。大量患者死于晚期远处转移,尤其是脑部转移。由于血脑屏障、血液-肿瘤屏障的存在,药物治疗效果欠佳。大量研究表明表达失衡的分子在肿瘤恶性进展中发挥重要作用,表皮生长因子受体、非编码RNA、细胞黏附分子等众多分子被报道参与调控非小细胞肺癌脑转移进程,同时在诊断、治疗及评估患者预后等方面具有极高的临床转化价值。本文现就近年来非小细胞肺癌脑转移相关研究进展作一综述,期望为以后的研究提供思路与线索。Lung cancer is a common malignant tumor with high morbidity and mortality. Many patients die of distant metastases, especially to the brain. Due to the existence of blood-brain barrier and blood-tumor barrier, drug therapy is not effective. Many studies have shown that imbalanced expression of molecules plays an important role in the progression of malignant tumors. Epidermal growth factor receptor, non-coding RNA, cell adhesion molecules and others are reported to participate in regulating the process of brain metastases from non-small cell lung cancer, they also have high clinical translational value in diagnosis, treatment and evaluation of patient prognosis. This paper summarizes the recent progress of brain metastasis in non-small cell lung cancer, hoping to provide ideas and clues for future research.

关 键 词：非小细胞肺癌 脑转移 表皮生长因子受体 非编码RNA 分子机制 

分 类 号：R73[医药卫生—肿瘤]