姜黄素与白藜芦醇治疗非酒精性脂肪性肝病的机制研究进展  

Research progress of Curcumin and Resveratrol in the treatment of nonalcoholic fatty liver disease

作　　者：贺玉慧 朱铭星 刘跃洋 赵若玮 黄鸣清[1] 施红[4] 郑燕芳[1] 林彦翔 HE Yuhui;ZHU Mingxing;LIU Yueyang;ZHAO Ruowei;HUANG Mingqing;SHI Hong;ZHENG Yanfang;LIN Yanxiang(College of Pharmacy,Fujian University of Traditional Chinese Medicine,Fujian Province,Fuzhou350100,China;College of Traditional Chinese Medicine,Fujian University of Traditional Chinese Medicine,Fujian Province,Fuzhou350122,China;College of Acupuncture and Moxibustion,Fujian University of Traditional Chinese Medicine,Fujian Province,Fuzhou350122,China;College of Integrated Traditional Chinese and Western Medicine,Fujian University of Traditional Chinese Medicine,Fujian Province,Fuzhou350122,China)

机构地区：[1]福建中医药大学药学院,福建福州350122 [2]福建中医药大学中医学院,福建福州350122 [3]福建中医药大学针灸学院,福建福州350122 [4]福建中医药大学中西医结合学院,福建福州350122

出　　处：《中国医药导报》2023年第1期57-60,共4页China Medical Herald

基　　金：国家自然科学基金资助项目(81973827)。

摘　　要：非酒精性脂肪性肝病(NAFLD)是指除饮酒外其他因素导致肝损伤引起的,以脂肪堆积为特征的肝病。其发病机制复杂,胰岛素抵抗、线粒体功能障碍、肠道菌群紊乱等因素均影响了NAFLD的发生、发展,核因子κB信号通路的激活、脂质过度堆积也可能参与其中。临床上缺乏治疗NAFLD的理想药物,其目前的治疗方法主要通过调控生活方式来减轻体重,改善代谢综合征的组分来缓解疾病。姜黄素和白藜芦醇皆是一种多酚类物质,都被发现是治疗NAFLD的潜在药物,并已开展了广泛的实验研究。本文系统归纳了姜黄素和白藜芦醇治疗NAFLD的作用机制研究进展。Non-alcoholic fatty liver disease(NAFLD) is defined as liver disease characterized by fat accumulation caused by factors other than alcohol consumption.The pathogenesis of NAFLD is complex,including insulin resistance,mitochondrial dysfunction,intestinal flora disorder and other factors affecting the occurrence and development of NAFLD,and the activation of nuclear factor-κB signaling pathway and lipid overaccumulation may also be involved.Clinically,there is a lack of ideal drugs for NAFLD treatment,and the current treatment methods are mainly to reduce weight by regulating lifestyle and improve the components of metabolic syndrome to alleviate the disease.Curcumin and resveratrol,both polyphenols,have been found to be potential drugs for the treatment of NAFLD,and extensive experimental studies have been carried out.This paper systematically summarizes the research progress on the mechanism of curcumin and resveratrol in the treatment of NAFLD,providing theoretical basis for the subsequent treatment of NAFLD and the clinical application of curcumin and resveratrol.

关 键 词：非酒精性脂肪性肝病 姜黄素 白藜芦醇 作用机制 

分 类 号：R575[医药卫生—消化系统]