血清TLR4水平与肺癌化疗后骨髓抑制的相关性分析  

Correlation analysis between serum TLR4 level and myelosuppression after chemotherapy for lung cancer

作　　者：刘梦瑶 罗莲 陈梓林 颜磊 周娜[1] 陈勇[1] LIU Meng-yao;LUO Lian;CHEN Zi-lin(Hematological Oncology Department,Shaoyang Central Hospital Affiliated to Nanhua University,Shaoyang 422000,China)

机构地区：[1]南华大学附属邵阳市中心医院血液肿瘤科,422000

出　　处：《中国现代药物应用》2023年第2期21-24,共4页Chinese Journal of Modern Drug Application

摘　　要：目的研究血清Toll样受体4(TLR4)水平与肺癌化疗后骨髓抑制的相关性。方法93例非小细胞肺癌患者,检测化疗前1d及化疗后第7天的血清TLR4水平。统计第1次化疗后骨髓抑制发生率,分析患者临床特征与骨髓抑制程度的相关性及化疗前后血清TLR4水平与骨髓抑制程度的相关性。结果93例中晚期非小细胞肺癌患者中共发生骨髓抑制78例(83.9%),其中0级15例(16.1%),Ⅰ级21例(22.6%),Ⅱ级40例(43.0%),Ⅲ级11例(11.8%),Ⅳ级6例(6.5%)。患者年龄<65岁、体质量指数<18.5 kg/m2的骨髓抑制程度与年龄≥65岁、体质量指数≥18.5 kg/m2比较,差异有统计学意义(P<0.05);不同性别、KPS评分、病理分型的骨髓抑制程度比较,差异无统计学意义(P>0.05)。化疗前,患者血清TLR4+的骨髓抑制程度与血清TLR4-比较,差异无统计学意义(P>0.05);化疗后,血清TLR4+的骨髓抑制程度与血清TLR4-比较,差异有统计学意义(P<0.05);化疗后血清TLR4水平与骨髓抑制程度呈正相关(r=0.540,P<0.05)。结论血清TLR4水平与非小细胞肺癌化疗后骨髓抑制存在相关性,TLR4可能参与了化疗后骨髓抑制的发生机制。Objective To study the correlation between serum TLR4 level and myelosuppression after chemotherapy for lung cancer.Methods In 93 patients with non-small cell lung cancer,serum TLR4 levels were measured 1 d before and on day 7 after chemotherapy.The incidence of myelosuppression after the first chemotherapy was counted,and the correlation between the clinical characteristics of patients and the degree of myelosuppression,and the correlation between serum TLR4 levels before and after chemotherapy and the degree of myelosuppression were analyzed.Results Among 93 patients with mid-to late-stage non-small cell lung cancer,myelosuppression occurred in 78 cases(83.9%),including 15 cases(16.1%)of grade 0,21 cases(22.6%)of gradeⅠ,40 cases(43.0%)of gradeⅡ,11 cases(11.8%)of gradeⅢ,and 6 cases(6.5%)of gradeⅣ.The degree of myelosuppression in patients aged<65 years and with a body mass index<18.5 kg/m2 were compared with those aged≥65 years and with a body mass index≥18.5 kg/m2,and the difference was statistically significant(P<0.05).The differences were not statistically significant when comparing the degree of myelosuppression by patient gender,KPS score,and pathological staging(P>0.05).Before chemotherapy,there was no statistically significant difference in the degree of myelosuppression in patients with serum TLR4+compared with serum TLR4-(P>0.05).After chemotherapy,there was a statistically significant difference in the degree of myelosuppression of serum TLR4+compared with that of serum TLR4-(P<0.05).There was a positive correlation between serum TLR4 levels and the degree of myelosuppression after chemotherapy(r=0.540,P<0.05).Conclusion Serum TLR4 level is correlated with myelosuppression after chemotherapy for non-small cell lung cancer,and TLR4 may be involved in the mechanism of myelosuppression after chemotherapy.

关 键 词：肺癌 化疗 骨髓抑制 TOLL样受体4 

分 类 号：R734.2[医药卫生—肿瘤]