度洛西汀联合高频重复经颅磁刺激治疗难治性抑郁症的疗效和安全性研究  

Study on the efficacy and safety of duloxetine combined with high-frequency repetitive transcranial magnetic stimulation for treatment-refractory depression

作　　者：李世利 LI Shi-li(Department of Psychiatry,Liaoyou Baoshihua Hospital,Panjin 124010,China)

机构地区：[1]盘锦辽油宝石花医院精神心理科,124010

出　　处：《中国实用医药》2023年第2期132-134,共3页China Practical Medicine

摘　　要：目的分析度洛西汀联合高频重复经颅磁刺激(rTMS)治疗难治性抑郁症(TRD)的临床效果及安全性。方法74例难治性抑郁症患者,按随机数字表法分为观察组和对照组,各37例。观察组采用度洛西汀联合高频重复经颅磁刺激治疗,对照组采用度洛西汀联合模拟高频重复经颅磁刺激治疗。对比两组临床疗效、不良反应发生率及汉密顿抑郁量表(HAMD)、临床总体印象量表-病情严重程度(CGI-S)、临床总体印象量表-总体改善(CGI-I)评分。结果治疗前,两组HAMD、CGI-S、CGI-I评分对比,差异无统计学意义(P>0.05);治疗后,观察组HAMD评分(10.35±4.06)分、CGI-S评分(1.89±0.52)分、CGI-I评分(1.95±0.26)分均明显低于对照组的(13.62±4.19)、(2.21±0.50)、(2.25±0.30)分,差异有统计学意义(P<0.05)。观察组治疗总有效率94.59%高于对照组的78.38%,差异有统计学意义(P<0.05)。观察组不良反应发生率为10.81%,与对照组的13.51%对比,差异无统计学意义(P>0.05)。结论难治性抑郁症患者应用度洛西汀联合高频重复经颅磁刺激治疗可获得确切的临床疗效,且安全性高。Objective To analyze the clinical effect and safety of duloxetine combined with highfrequency repetitive transcranial magnetic stimulation(rTMS)for treatment-refractory depression(TRD).Methods A total of 74 patients with treatment-refractory depression were divided into observation group and control group according to random numerical table method,with 37 cases in each group.The observation group was treated with duloxetine combined with high-frequency repetitive transcranial magnetic stimulation,and the control group was treated with duloxetine combined with simulated high-frequency repetitive transcranial magnetic stimulation.Both groups were compared in terms of clinical efficacy,the incidence of adverse reactions and Hamilton depression scale(HAMD)score,clinical global impression-severity(CGI-S)score and clinical global impressionimprovement(CGI-I)score.Results Before treatment,there was no statistically significant difference between the two groups in terms of HAMD,CGI-S and CGI-I scores(P>0.05).After treatment,the HAMD score(10.35±4.06)points,CGI-S score(1.89±0.52)points and CGI-I score(1.95±0.26)points of the observation group were significantly lower than(13.62±4.19),(2.21±0.50)and(2.25±0.30)points of the control group,and the differences were statistically significant(P<0.05).The total effective rate of treatment in the observation group was 94.59%,which was higher than 78.38%in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 10.81%,and the difference was not statistically significant compared with 13.51%in the control group(P>0.05).Conclusion Duloxetine combined with high-frequency repetitive transcranial magnetic stimulation can obtain definite clinical efficacy and high safety for treatment-refractory depression patients.

关 键 词：难治性抑郁症 度洛西汀 高频重复经颅磁刺激 安全性 

分 类 号：R749.4[医药卫生—神经病学与精神病学]