清胰化积汤联合介入化疗栓塞治疗晚期胰腺癌临床研究  

Efficacy of Qingyi Huaji decoction combined with interventional chemoembolization in the treatment of advanced pancreatic cancer

作　　者：陈娟 朱凤婷 冯冬婵 麦丽珍[1] CHEN Juan;ZHU Fengting;FENG Dongchan;MAI Lizhen(Hainan Hospital of Traditional Chinese Medicine,Haikou 570203,China)

机构地区：[1]海南省中医院,海南海口570203

出　　处：《陕西中医》2023年第2期178-182,共5页Shaanxi Journal of Traditional Chinese Medicine

基　　金：海南省卫生健康行业科研项目(20A200516)。

摘　　要：目的:探讨清胰化积汤联合介入化疗栓塞治疗晚期胰腺癌的疗效及对患者血清免疫抑制酸性蛋白(IAP)、碱性纤维母细胞生长因子(bFGF)及可溶性肿瘤坏死因子受体Ⅰ(sTNFRⅠ)的影响。方法:92例晚期胰腺癌患者,以随机数字表法分为研究组和对照组,各46例。对照组接受介入化疗栓塞,研究组在对照组的基础上接受清胰化积汤治疗,两组治疗时间均为8周。对比两组中医症候积分、糖类抗原199(CA_(199))、癌胚抗原(CEA)、自然杀伤T细胞(NKT)、IAP、bFGF、sTNFRⅠ、卡氏功能状态(KPS)评分、生活质量评分表(QOL)、不良反应及临床疗效,记录两组生存情况。结果:治疗后两组中医症候积分均降低,研究组降低更明显(P<0.05)。治疗后两组CA_(199)、CEA均降低,且研究组更低(P<0.05);治疗后两组NKT均升高,研究组升高更明显(P<0.05);治疗后两组IAP、bFGF、sTNFRⅠ均降低,且研究组更低(P<0.05)。治疗后两组KPS评分、QOL评分均升高,且研究组更高(P<0.05);两组Ⅰ-Ⅳ级肝肾功能损害、胃肠道反应、骨髓抑制发生率比较差异无统计学意义(P>0.05)。研究组生存率高于对照组(P<0.05);研究组总有效率较对照组高(P<0.05)。结论:清胰化积汤联合介入化疗栓塞治疗晚期胰腺癌可改善患者临床症状、肿瘤标志物水平与免疫功能,提高患者生活质量,且安全性与预后良好。Objective:To investigate the efficacy of Qingyi Huaji decoction combined with interventional chemoembolization in the treatment of advanced pancreatic cancer and its effects on serum immunosuppressive acidic protein(IAP),basic fibroblast growth factor(bFGF)and soluble tumor necrosis factor receptorⅠ(sTNFRⅠ).Methods:92 patients with advanced pancreatic cancer were randomly divided into study group(46 cases)and control group(46 cases).The control group received interventional chemoembolization,and the study group received Qingyi Huaji decoction on the basis of the control group.The treatment time of both groups was 8 weeks.Two groups of TCM symptom scores,carbohydrate antigen 199(CA_(199)),carcinoembryonic antigen(CEA),natural killer T cells(NKT),IAP,bFGF,sTNFRⅠ,Karnofsky functional status(KPS)score,quality of life score table(QOL),adverse reactions and clinical efficacy were compared.After 3 years of follow-up,the survival of the two groups was recorded.Results:After treatment,TCM symptom scores in both groups were decreased,and the research group was lower(P<0.05).After treatment,CA_(199)and CEA in the two groups were decreased,and lower in the study group(P<0.05).After treatment,NKT increased was higher in the study group(P<0.05).After treatment,IAP,bFGF and sTNFRⅠin the two groups were decreased,and lower in the study group(P<0.05).After treatment,the KPS score and QOL score of the two groups were increased,and the research group was higher(P<0.05).There was no difference in the incidence ofⅠ-Ⅳclass liver and kidney function damage,gastrointestinal tract reaction and bone marrow suppression between the two groups(P>0.05).The survival rate of the study group was higher than that of the control group(P<0.05).The total effective rate in the study group was higher than that in the control group(P<0.05).Conclusion:Qingyi Huaji decoction combined with interventional chemoembolization has a definite curative effect in the treatment of advanced pancreatic cancer,and can improve the clinical symptoms,tumor m

关 键 词：胰腺癌 清胰化积汤 介入化疗栓塞 免疫抑制酸性蛋白 碱性纤维母细胞生长因子 可溶性肿瘤坏死因子受体Ⅰ 

分 类 号：R735.9[医药卫生—肿瘤]