间充质干细胞和神经细胞共培养技术及其应用研究进展  

Research progress on co-culture and application of mesenchymal stem cells and nerve cells

作　　者：刘鸣一 张滋彬 时嘉悦 马雨轩 焦凯 牛丽娜 Liu Ming-Yi;Zhang Zi-Bin;Shi Jia-Yue;Ma Yu-Xuan;Jiao Kai;Niu Li-Na(State Key Laboratory of Military Stomatology/National Clinical Research Center for Oral Diseases/Shaanxi Key Laboratory of Stomatology/Department of Prosthodontics,School of Stomatology,Air Force Military Medical University,Xi’an,Shaanxi 710032,China;State Key Laboratory of Military Stomatology/National Clinical Research Center for Oral Diseases/Shaanxi Clinical Research Center for Oral Diseases/Department of Mucosal Diseases,School of Stomatology,Air Force Military Medical University,Xi’an,Shaanxi 710032,China)

机构地区：[1]空军军医大学口腔医院修复科/军事口腔医学国家重点实验室/口腔疾病国家临床医学研究中心/陕西省口腔医学重点实验室,陕西西安710032 [2]空军军医大学口腔医院黏膜病科/军事口腔医学国家重点实验室/口腔疾病国家临床医学研究中心/陕西省口腔疾病临床医学研究中心,陕西西安710032

出　　处：《解放军医学杂志》2022年第12期1256-1261,共6页Medical Journal of Chinese People's Liberation Army

基　　金：国家自然科学基金(81870805);陕西省重点科技创新团队计划项目(2020TD-033)。

摘　　要：体外细胞共培养是一项研究特定生物学问题的重要技术,近年来被广泛应用于神经系统疾病的研究中。神经系统疾病具有多样性、常见性、难治性等特点,一直是科研人员致力攻克的医学难题。间充质干细胞(MSCs)和神经细胞共培养技术为治疗神经系统疾病带来了希望。该技术实现了在一个系统设计和控制的共培养环境中,探索神经细胞在生理、病理或毒性条件下的形态和功能,以及细胞间相互作用的分子事件。MSCs指导的神经发生和神经再生将对神经系统疾病未来的治疗策略产生重大影响。本文系统性回顾MSCs与神经细胞共培养技术的进展,阐述共培养模型的应用前景,旨在为神经系统疾病的治疗提供新思路。Co-culture is an important technique to study specific biological problems,and has been widely applied recent years in the field of nervous system diseases which are characterized by diversity,commonality and intractability,and have always been a medical problem that researchers are committed to overcoming.The co-culture of mesenchymal stem cells(MSCs)and nerve cells provides hope for treatment of nervous system diseases.As a systemically designed and controlled environment,co-culture technology can be used to explore the morphology and function of nerve cells under physiological,pathological or toxic conditions,as well as the molecular events of intercellular interaction.Neurogenesis and nerve regeneration directed by MSCs will have a significant impact on therapeutic strategies for neurological diseases in the future.The research progress in co-culture of MSCs and nerve cells has been systematically reviewed in present paper,and described the application prospect of co-culture model,so as to provide ideas for the treatment of nervous system diseases.

关 键 词：间充质干细胞 神经元 共同培养技术 神经胶质 神经系统疾病 

分 类 号：R394.2[医药卫生—医学遗传学]