复合植物提取物对羔羊腹泻、血清免疫、炎症反应和抗氧化能力的影响  

Effects of Compound Plant Extracts on Diarrhea,Serum Immunity,Inflammatory Response and Serum Antioxidant Capacity of Lambs

作　　者：刘凯伟 吕慧源[3] 屠焰[1] 成述儒[2] 郭春燕[4] 刁其玉[1] 毕研亮[1] LIU Kaiwei;LYU Huiyuan;TU Yan;CHENG Shuru;GUO Chunyan;DIAO Qiyu;BI Yanliang(Institute of Feed Research of Chinese Academy of Agricultural Sciences,Key Laboratory of Biotechnology Feed,Ministry of Agriculture and Rural Affairs,Beijing 100081,China;College of Animal Science and Technology,Gansu Agricultural University,Gansu Lanzhou 730070,China;Beijing Centre Biology Co.,Ltd.,Beijing 102629,China;Department of Bioengineering)

机构地区：[1]中国农业科学院饲料研究所,农业农村部饲料生物技术重点实验室,北京100081 [2]甘肃农业大学动物科学技术学院,甘肃兰州730070 [3]北京生泰尔科技股份有限公司,北京102629 [4]晋中职业技术学院生物工程系,山西晋中030600

出　　处：《饲料工业》2023年第2期39-44,共6页Feed Industry

基　　金：中国农业科学院基本科研业务费专项[1610382021004];山西省基础研究计划[20210302124338]。

摘　　要：试验旨在研究不同比例复合植物提取物对湖羊羔羊腹泻频率、血清指标的影响。试验选取15日龄的湖羊羔羊135只,随机分为5个组。对照组(CON)、A、B、C、D组分别在开食料的基础上添加0、0.5、1.0、1.5、2.0 g/kg复合植物提取物,饲养试验共84 d。结果表明:在断奶前后各添加剂组羔羊的腹泻频率均低于对照组,但差异不显著(P>0.05)。试验结束时各组羔羊的体重无显著差异(P>0.05)。C组的免疫球蛋白G、A、M含量均显著高于对照组和其他试验组(P<0.05)。C组的白细胞介素4、10、转化生长因子β均显著高于对照组和其他试验组(P<0.05),白细胞介素6、17A、8、22和肿瘤坏死因子α均显著低于对照组和其他试验组(P<0.05)。C组的超氧化物歧化酶、谷胱甘肽过氧化物酶、总抗氧化能力均显著高于对照组和其他试验组(P<0.05),丙二醛含量显著低于对照组和其他试验组(P<0.05)。综上,在饲粮中添加适宜量的复合植物添加剂可以降低羔羊的腹泻频率,添加1.5 g/kg的复合植物提取物可以增加羔羊的免疫能力和抗氧化能力,提高羔羊的抗病力。The purpose of this experiment was to study the effects of dietary supplementation with different proportions of compound plant extracts on diarrhea frequency,serum immunity,inflammatory response and antioxidant capacity of Hu lambs.A total of 135 healthy 15-day-old Hu lambs with similar body weight(5.40±0.75)kg were randomly divided into five groups.The control group(CON)and the experimental groups A,B,C,and D were fed with starter supplemented with 0,0.5,1.0,1.5 g/kg and 2.0 g/kg compound plant extract,respectively.The experiment lasted for 84 days.The results showed that before and after weaning,the diarrhea frequency of lambs in the compound plant extract groups were lower than that in the control group,but there was no significant difference among the groups.The IgA,IgM,and IgG in group C were significantly higher than those in control group and other experimental groups(P<0.05).The serum anti-inflammatory cytokines IL-4,IL-6 and TGF-βin groups C were significantly higher than those in other groups(P<0.05),and the pro-inflammatory cytokines IL-6,IL-8,IL-17A,IL-22 and TNF-αin group C were significantly lower than those in other groups(P<0.05).The SOD,GSH-Px and T-AOC in groups C were significantly higher than those in other groups(P<0.05).The MDA in groups C were significantly lower than those in other groups(P<0.05).In conclusion,dietary supplementation with appropriate amount of compound plant extract can reduce the frequency of diarrhea.Supplementation of 1.5 g/kg compound plant extract in diet could improve the immune capacity and antioxidant capacity of lambs and reduce the incidence rate of lambs.

关 键 词：植物提取物 羔羊 腹泻 血清免疫 炎症反应 抗氧化能力 

分 类 号：S816.32[农业科学—饲料科学]