Osteoarthritis animal models for biomaterial-assisted osteochondral regeneration  

作　　者：Yi Wang Yangyang Chen Yulong Wei 

机构地区：[1]Department of Radiology,Zhongnan Hospital of Wuhan University,Wuhan,Hubei Province,China [2]Department of Orthopaedics,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei Province,China.

出　　处：《Biomaterials Translational》2022年第4期264-279,共16页生物材料转化电子杂志（英文）

基　　金：This work was supported by the National Key R&D Program of China(No.2021YFA1102600);the National Natural Science Foundation of China(No.82002315).

摘　　要：Clinical therapeutics for the regeneration of osteochondral defects(OCD)in the early stages of osteoarthritis remain an enormous challenge in orthopaedics.For in-depth studies of tissue engineering and regenerative medicine in terms of OCD treatment,the utility of an optimal OCD animal model is crucial for assessing the effects of implanted biomaterials on the repair of damaged osteochondral tissues.Currently,the most frequently used in vivo animal models for OCD regeneration include mice,rats,rabbits,dogs,pigs,goats,sheep,horses and nonhuman primates.However,there is no single“gold standard”animal model to accurately recapitulate human disease in all aspects,thus understanding the benefits and limitations of each animal model is critical for selecting the most suitable one.In this review,we aim to elaborate the complex pathological changes in osteoarthritic joints and to summarise the advantages and limitations of OCD animal models utilised for biomaterial testing along with the methodology of outcome assessment.Furthermore,we review the surgical procedures of OCD creation in different species,and the novel biomaterials that promote OCD regeneration.Above all,it provides a significant reference for selection of an appropriate animal model for use in preclinical in vivo studies of biomaterial-assisted osteochondral regeneration in osteoarthritic joints.

关 键 词：animal model biomaterial osteochondral defect REGENERATION 

分 类 号：R318[医药卫生—生物医学工程]