视网膜色素上皮细胞间紧密连接及其在AMD发病过程中的作用研究进展  

Research progress of tight junction between retinal pigment epithelium cells and its disruption in the pathogenesis of age-related macular degeneration

作　　者：王巧云 解来青[1] Qiao-Yun Wang;Lai-Qing Xie(Department of Ophthalmology,the Second Affiliated Hospital of Soochow University,Suzhou 215004,Jiangsu Province,China)

机构地区：[1]苏州大学附属第二医院眼科,江苏省苏州市215004

出　　处：《国际眼科杂志》2023年第2期232-235,共4页International Eye Science

基　　金：江苏省卫生健康委医学科研项目(No.M2020053);苏州市医疗卫生科技创新(应用基础研究)(No.SKJY2021083)。

摘　　要：年龄相关性黄斑变性(AMD)是引起老年人群不可逆性视力损害的常见眼病。视网膜色素上皮细胞(RPECs)间紧密连接(TJ)是血-视网膜外屏障(oBRB)的重要结构单元。紧密连接在AMD的发病过程中有所缺陷,进而促进oBRB的破坏,加速AMD的发生和进展。本文将对紧密连接与紧密连接蛋白在维持oBRB功能、紧密连接蛋白异常与oBRB破坏在AMD发病过程中的作用研究进行综述,以期为AMD治疗的研究提供新的思路。Age-related macular degeneration(AMD)is a common eye disease causing irreversible visual impairment in the elderly.The tight junction(TJ)between retinal pigment epithelium cells(RPECs)is an important structural unit of the outer blood retinal barrier(oBRB).The TJ is defective in the pathogenesis of AMD,which in turn promotes the destruction of oBRB and accelerates the occurrence and progression of AMD.In this paper,the roles of TJ and TJ protein in maintaining oBRB function,TJ protein abnormality and oBRB destruction in the pathogenesis of AMD were reviewed,aiming to provide new ideas for the treatment of AMD.

关 键 词：年龄相关性黄斑变性(AMD) 血-视网膜外屏障 视网膜色素上皮 紧密连接 

分 类 号：R774.5[医药卫生—眼科]