0.05%环孢素A治疗干眼有效性和安全性Meta分析  

Meta-analysis of the efficacy and safety of 0.05%cyclosporine A in the treatment of dry eye

作　　者：田小辉 胡鹿梅 易湘龙[1] 张宏[1] Xiao-Hui Tian;Lu-Mei Hu;Xiang-Long Yi;Hong Zhang(Department of Ophthalmology,First Affiliated Hospital of Xinjiang Medical University,Urumqi 830000,Xinjiang UygurAutonomous Region,China)

机构地区：[1]新疆医科大学第一附属医院眼科,新疆维吾尔自治区乌鲁木齐市830000

出　　处：《国际眼科杂志》2023年第2期248-255,共8页International Eye Science

基　　金：国家自然科学基金资助项目(No.81960181)。

摘　　要：目的:对0.05%环孢素A(CsA)滴眼液治疗干眼的安全性和有效性进行系统评价。方法:检索PubMed、Web of Science、Cochrane图书馆、Embase、中国生物医学文献数据库、中国知网数据库、维普中文科技期刊数据库、万方数据库。纳入各数据库2016-01-01/2022-03-280.05%CsA滴眼液治疗干眼的随机对照试验。CsA组采用0.05%CsA滴眼液治疗,对照组采用人工泪液、安慰剂等进行治疗。采用ReMan 5.3软件对治疗后泪液分泌试验(SⅠt)、泪膜破裂时间(BUT)、角膜荧光素染色(CFS)、眼表疾病指数(OSDI)、不良反应进行Meta分析。结果:共纳入13篇文献,共1164例2057眼。与对照组相比,CsA组SⅠt延长(MD=2.04,95%CI:1.75~2.33,P<0.00001),BUT更久(MD=1.32,95%CI:0.87~1.76,P<0.00001),CFS降低(MD=-0.79,95%CI:-1.20~-0.39,P=0.0001),OSDI降低(MD=-5.52,95%CI:-9.14~-1.91,P=0.003)。但CsA组出现不良反应更多(OR=1.69,95%CI:1.06~2.72,P=0.03)。结论:0.05%CsA可改善干眼患者的主观症状及各项客观指标。但与人工泪液等药物相比,0.05%CsA治疗后出现的眼部烧灼感等不良反应更多。AIM:To systematically evaluate the safety and efficacy of 0.05%cyclosporine A(CsA)in the treatment of dry eye.METHODS:PubMed,Web of Science,Cochrane Library,Embase,Chinese Bio-Medical Literature Database,CNKI,VIP,and Wan Fang Database were retrieved.Randomized controlled trials related to the treatment of dry eye with 0.05%CsA from January 1,2016 to March 28,2022 in each database were included.The CsA group was treated with 0.05%CsA eye drops,and the control group was treated with artificial tears and placebo.ReMan 5.3 was used for Meta-analysis of post-treatment SchirmerⅠtest(SⅠt),break up time(BUT),corneal fluorescein staining(CFS),ocular surface disease index(OSDI)and adverse effects.RESULTS:A total of 13 literatures were included,which included 1164 cases(2057 eyes).Compared with the control group,the SIt in the CsA group was prolonged(MD=2.04,95%CI:1.75~2.33,P<0.00001),BUT was longer(MD=1.32,95%CI:0.87~1.76,P<0.00001),CFS decreased(MD=-0.79,95%CI:-1.20~-0.39,P=0.0001)and OSDI decreased(MD=-5.52,95%CI:-9.14~-1.91,P=0.003).However,the CsA group had more adverse reactions(OR=1.69,95%CI:1.06~2.72,P=0.03).CONCLUSION:0.05%CsA can improve the subjective symptoms and various objective indicators of dry eye patients.However,0.05%CsA seems to produce more adverse effects,like ocular burning sensation when compared to drugs such as artificial tears.

关 键 词：环孢素A 干眼 效果 安全性 META分析 

分 类 号：R777.34[医药卫生—眼科]