甲状腺乳头状癌患者术后血清MMIF和IL-6表达水平与甲状旁腺功能减退持续时间的相关性研究  

Correlation between Postoperative Serum MMIF and IL-6 Expression Levels and Duration of Hypoparathyroidism in Patients with Papillary Thyroid Cancer

作　　者：那将超[1] 狄长安[1] NA Jiang-chao;DI Chang-an(Department of General Surgery,Beijing Pinggu Hospital,Beijing 101200,China)

机构地区：[1]北京市平谷区医院普外科,北京101200

出　　处：《现代检验医学杂志》2023年第1期191-194,共4页Journal of Modern Laboratory Medicine

基　　金：北京市平谷区医院科研项目(pgyy2021-05)。

摘　　要：目的探究甲状腺乳头状癌患者术后血清巨噬细胞移动抑制因子(macrophage movement inhibitory factor,MMIF)和白细胞介素(interleukin,IL)-6表达水平与甲状旁腺功能减退持续时间的关系。方法选取北京市平谷区医院2020年5月~2022年2月133例甲状腺乳头状癌术后甲状旁腺功能减退患者,根据甲状旁腺功能减退持续时间的中位数将其分为长时组(>8周,n=65)和短时组(≤8周,n=68)。酶联免疫吸附法检测血清MMIF和IL-6水平,并分析二者与甲状旁腺功能减退持续时间的关系。结果长时组和短时组的年龄、女性占比、体质量指数、肿瘤直径、双侧中央区淋巴结清扫占比、术后引流量、包膜侵犯占比、甲状旁腺意外切除占比、术前血钙和甲状旁腺激素、术后第1天的肿瘤坏死因子-α水平,差异均无统计学意义(t/χ^(2)/Z=0.123~1.401,均P>0.05)。与短时组相比,长时组的手术时间[114(102,139)min vs 101(95,114)min]、术后第1天的MMIF(2.38±0.26 ng/ml vs 2.09±0.19ng/ml)和IL-6水平[14.10(12.47,15.13)ng/L vs 12.42(11.61,13.38)ng/L]均升高,差异具有统计学意义(Z/t=3.419~7.185,均P<0.05)。Pearson分析结果显示log10(甲状旁腺功能减退持续时间)与MMIF呈正相关关系(r=0.397,P=0.000)。Spearman分析结果显示甲状旁腺功能减退持续时间与手术时间和IL-6均呈正相关关系(rs=0.363,P=0.000;rs=0.281,P=0.001)。线性回归分析结果显示手术时间(t=2.734,P=0.007)、MMIF(t=4.265,P=0.000)和IL-6(t=3.006,P=0.003)均与甲状旁腺功能减退持续时间独立相关。结论MMIF和IL-6与甲状旁腺功能减退持续时间呈正相关关系,二者水平高提示患者甲状旁腺功能减退持续时间长。Objective To investigate the relationship between postoperative serum macrophage movement inhibitory factor(MMIF)and interleukin-6(IL-6)expression levels and the duration of postoperative hypoparathyroidism in patients with papillary thyroid cancer.Methods 133 patients with postoperative hypoparathyroidism in papillary thyroid cancer in Beijing Pinggu Hospital from May 2020 to February 2022 were selected as the study subjects.Patients were divided into the long duration group(>8 weeks,n=65)and the short duration group(≤8 weeks,n=68)based on the median duration of hypoparathyroidism.Serum MMIF and IL-6 levels were measured by enzyme-linked immunosorbent assay(ELISA),and their relationship with the duration of hypoparathyroidism was analyzed.Results The differences of age,proportion of females,body mass index,tumour diameter,percentage of lymph node dissection in the central region bilaterally,postoperative drainage,percentage of envelope violations,accidental parathyroidectomy,preoperative blood calcium and parathyroid hormone,and tumour necrosis factor-αon postoperative day 1th in the long duration group and the short duration group were not statistically significant(t/χ^(2)/Z=0.123~1.401,all P>0.05).Compared with the short duration group,the levels of operative time[114(102,139)min vs 101(95,114)min],MMIF(2.38±0.26 ng/ml vs 2.09±0.19 ng/ml)and IL-6[14.10(12.47,15.13)ng/L vs 12.42(11.61,13.38)ng/L]in the long duration group were elevated(Z/t=3.419~7.185,all P<0.05).Pearson analysis showed a positive correlation between log10(duration of hypoparathyroidism)and MMIF(r=0.397,P=0.000).Spearman analysis showed a positive correlation between the duration of hypoparathyroidism and both the operation time and IL-6(rs=0.363,0.281,P=0.000,0.001).Linear regression analysis showed that operation time(t=2.734,P=0.007),MMIF(t=4.265,P=0.000)and IL-6(t=3.006,P=0.003)were all independently associated with the duration of hypoparathyroidism.Conclusion MMIF and IL-6 were positively correlated with the duration of hypoparathyr

关 键 词：巨噬细胞移动抑制因子 白细胞介素-6 甲状腺乳头状癌 甲状旁腺功能减退 

分 类 号：R736.1[医药卫生—肿瘤] R730.43[医药卫生—临床医学]