SWE检查联合氯离子通道蛋白-3在诊断宫颈癌中的应用  

Application of SWE Combined with Chloride Channel Protein-3 in the Diagnosis of Cervical Cancer

作　　者：陶玉华[1] 缪娴[1] 纪红娟[1] 顾小侠[1] TAO Yuhua;MIAO Xian;JI Hongjuan;GU Xiaoxia(Department of Oncology,Nantong Hospital of Traditional Chinese Medicine,Nantong 226001,Jiangsu,P.R.China)

机构地区：[1]南通市中医院肿瘤内科,江苏南通226001

出　　处：《影像科学与光化学》2023年第1期142-146,共5页Imaging Science and Photochemistry

基　　金：吴阶平医学基金会临床科研课题(320.6750.18109)。

摘　　要：本文探究实时剪切波弹性成像(SWE)联合氯离子通道蛋白-3(ClC-3)诊断宫颈癌的价值。选取疑似宫颈病变的105例患者作为研究对象,包括50例良性病变患者(良性病变组)和55例宫颈癌患者(宫颈癌组),选取同期50例体检健康者作为对照组。通过SWE检查所有受试者的弹性模量最大值、弹性模量平均值。采用实时荧光定量聚合酶链反应(PCR)法测定血清ClC-3 mRNA水平。以临床病理诊断为金标准,通过ROC曲线评价弹性模量最大值、弹性模量平均值、血清ClC-3 mRNA诊断宫颈癌的价值。与对照组和良性病变组相比,宫颈癌组患者弹性模量最大值、弹性模量平均值、血清ClC-3 mRNA水平升高(P<0.05)。弹性模量最大值和弹性模量平均值均与ClC-3 mRNA显著正相关(r=0.447,P<0.001),与单一检查相比,弹性模量最大值、弹性模量平均值、ClC-3 mRNA联合诊断宫颈癌的AUC和敏感度升高(P<0.05)。SWE成像参数与血清ClC-3 mRNA变化与宫颈癌发生具有一定相关性,SWE联合血清ClC-3 mRNA检查具有较高的宫颈癌诊断价值。This paper explored the value of real-time shear-wave elastography(SWE)combined with chloride channel protein-3(ClC-3)in the diagnosis of cervical cancer.105 patients with suspected cervical lesions were selected as the research objects,including 50 cases with benign lesions(benign lesion group)and 55 cases with cervical cancer(cervical cancer group).At the same time,50 healthy people in the same period were selected as the control group.The maximum and average elastic modulus of all subjects were examined by SWE.Serum ClC-3 mRNA level was determined by real-time polymerase chain reaction(PCR).Using clinicopathological diagnosis as the gold standard,ROC curve was used to evaluate the diagnostic value of maximum elastic modulus,average elastic modulus and serum ClC-3 mRNA in cervical cancer.Compared with the control group and the benign lesion group,the maximum elastic modulus,the average elastic modulus,and the serum ClC-3 mRNA level were increased in the cervical cancer group(P<0.05).The maximum value of elastic modulus and the average value of elastic modulus were positively correlated with ClC-3 mRNA(r=0.447,P<0.001).Compared with single examination,the AUC and sensitivity of combined detection of the maximum elastic modulus,average elastic modulus and ClC-3 mRNA were increased(P<0.05).SWE imaging parameters and serum ClC-3 mRNA changes have a certain correlation with the occurrence of cervical cancer.SWE combined with serum CLC-3 mRNA examination has high diagnostic value for cervical cancer.

关 键 词：实时剪切波弹性成像 氯离子通道蛋白-3 宫颈癌 

分 类 号：R737.33[医药卫生—肿瘤]