鳞状细胞癌抗原对宫颈鳞癌淋巴结转移的预测价值  

Predictive Value of Squamous Cell Carcinoma Antigen in Lymph Node Metastasis of Cervical Squamous Cell Carcinoma

作　　者：吕加金 顾濛 胡晓静 苏畑璐 靳双玲[2] LÜ Jiajin;GU Meng;HU Xiaojing;SU Tianlu;JIN Shuangling(The First Clinical College of Changzhi Medical College)

机构地区：[1]长治医学院第一临床学院,046000 [2]长治医学院附属和平医院妇科

出　　处：《长治医学院学报》2022年第6期446-449,共4页Journal of Changzhi Medical College

摘　　要：目的:探讨鳞状细胞癌抗原(SCC-Ag)对宫颈鳞状细胞癌淋巴结转移的预测价值。方法:回顾性分析经手术治疗的110例宫颈鳞癌患者临床及病理资料,根据术后病检结果分为淋巴结转移组20例和淋巴结未转移组90例,比较2组临床和病理特征,采用多因素Logistic回归分析淋巴结转移的独立危险因素,绘制ROC曲线确定SCC-Ag预测淋巴结转移的诊断准确率和最佳截断值。结果:淋巴结转移组与淋巴结未转移组的年龄、体质量指数、是否侵犯阴道壁、肿瘤直径、宫颈间质浸润深度等病理特征比较差异均无统计学意义(P>0.05);2组间术前SCC-Ag水平和肿瘤分化程度差异有统计学意义(P<0.05);多因素Logistic回归分析提示高SCC-Ag值、肿瘤中低分化程度是淋巴结转移的独立危险因素;ROC曲线提示SCC-Ag预测淋巴结转移的灵敏度为80.0%,特异度为47.8%,曲线下面积为0.660,最佳截断值为2.115 ng·mL^(-1)。结论:高SCC-Ag水平,中低分化是宫颈鳞癌淋巴结转移的危险因素,SCC-Ag对宫颈鳞癌淋巴结转移可能有一定的预测价值。Objective:To investigate the predictive value of squamous cell carcinoma antigen(SCC-Ag)on lymph node metastasis of cervical squamous cell carcinoma.Methods:The clinical and pathological data of 110 patients with cervical squamous cell carcinoma treated by operation were retrospectively analyzed.According to the postoperative pathological examination results,they were divided into the lymph node metastasis group(n=20)and the lymph node non-metastasis group(n=90).T-test,Mann-Whitney rank-sum test and Chi-square test were used to compare the clinical and pathological features of the lymph node metastasis group and the non-metastasis group.Multivariate Logistic regression analysis was conducted to analyze the independent risk factors of lymph node metastasis.ROC curve was drawn to determine the diagnostic accuracy and optimal cut-off value of SCC-Ag in predicting lymph node metastasis.Results:There were no statistically significant differences in age,body mass index,tumor diameter,depth of cervical interstitial infiltration,and other pathological features between the group with lymph node metastasis and the group without lymph node metastasis(P>0.05),but there were statistically significant differences between the group with preoperative SCC-Ag level,degree of tumor differentiation and presence of vaginal wall metastasis(P<0.05).Multivariate Logistic regression analysis showed that SCC value and differentiation degree(medium and low differentiation)were independent risk factors for lymph node metastasis.ROC curve indicated that SCC-Ag had a sensitivity of 80.0%,specificity of 47.8%,area under the curve of 0.660,and an optimal cut-off value of 2.115 ng•mL-1 for lymph node prediction.Conclusion:SCC-Ag may have certain predictive values for cervical squamous cell carcinoma lymph node metastasis.

关 键 词：鳞状细胞相关抗原 宫颈癌 淋巴结转移 

分 类 号：R736.1[医药卫生—肿瘤]