香豆素类杂环化合物的抗微生物活性研究进展  

Recent Progress on the Antimicrobial Activities of Coumarin-derived Heterocyclic Compounds

作　　者：彭莘媚 王江河 贺银菊 李云萍 陈汉生 慈成刚 PENG Xin-mei;WANG Jiang-he;HE Yin-ju;LI Yun-ping;CHEN Han-sheng;CI Cheng-gang(School of Chemistry and Chemical Engineering,Qiannan Normal University for Nationalities,Duyun 558000,China)

机构地区：[1]黔南民族师范学院化学化工学院,贵州都匀558000

出　　处：《化学试剂》2023年第2期11-21,共11页Chemical Reagents

基　　金：贵州省教育厅青年科技人才成长项目(黔教合KY字[2018]431);黔南民族师范学院校级项目(qnsyrc-201613,qnsy2018014,Qnsyk201603,QNSYCXYJD2018005);国家自然科学基金资助项目(22163007);贵州省自然科学基金项目([2020]1Y050);大学生创新创业训练计划资助项目(2018521328)。

摘　　要：香豆素母核反应活性高,结构修饰性强,易引入多种官能团实现结构多样化,在医药、农药、香料、材料等多种领域具有较高的应用价值。杂环修饰的香豆素类化合物具有广泛的生物活性、多靶点的作用机制、更强的选择性及更低的毒性等特点,在医药领域的研究一直是研究者们关注的热点。随着微生物耐药性的加剧,寻找有效且不易引起菌株产生耐药性的抗感染药物迫在眉睫。综述了近5年来香豆素类杂环化合物在抗细菌、抗结核及抗真菌3个方面的生物活性研究概况,以期为相关研究提供参考。Coumarin core has high chemical reactivity.It is much easy to be introduced into a variety of functional groups to achieve its derivatives with different applications,which are widely used in medicine,pesticides,spices,materials and other fields.Coumarins modified by heterocycles possess diverse biological activities,multi-targets mechanism,stronger selectivity and lower toxicity.These advantages make them become the focus for researchers in medicine field.With the rapid increase of microbial resistance,it is urgent to search for effective anti-infective drugs with no or little resistance.The present review aimed to highlight the current progress on the antibacterial,antituberculotic and antifungal activities of coumarin heterocyclic compounds in the past five years.It is hopeful to provide reference for future exploration.

关 键 词：香豆素 杂环化合物 抗细菌 抗结核 抗真菌 

分 类 号：R914.4[医药卫生—药物化学]