感染性疾病与程序性细胞死亡相关性研究新进展  

Research advances on the relationship between infectious diseases and programmed cell death

作　　者：马亦林[1] Ma Yilin(Department of Infectious Diseases,State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China)

机构地区：[1]传染病诊治国家重点实验室、国家感染性疾病临床医学研究中心、浙江大学医学院附属第一医院感染病科,杭州310003

出　　处：《中华临床感染病杂志》2022年第5期333-344,共12页Chinese Journal of Clinical Infectious Diseases

摘　　要：近年来,随着细胞死亡分子机制方面的研究取得进展,人们才逐渐发现有多种新型的细胞程序性死亡方式,包括非凋亡性(10种)及凋亡性(2种)二大类。它们广泛参与感染性疾病和肿瘤等疾病的发生、发展,是目前热门研究的前沿课题,为临床防治提供了新思路。本文通过对程序性细胞死亡文献的梳理,围绕细胞坏死、凋亡、焦亡、铁死亡、中性粒细胞的炎性细胞死亡、铜死亡及细胞广泛凋亡等特征性表现,以及与若干感染性疾病相关性研究进展作一综述。In recent years,with the progress of research on the molecular mechanism of cell death,it has been discovered that there are many new types of programmed cell death,including non-apoptotic(10 types)and apoptotic(2 types),which are widely involved in the pathogenesis of infectious diseases and tumors.It is also a frontier research topic and provides new ideas for disease prevention and treatment.This article reviews the published literature on programmed cell death,focusing on the characteristics of cell necrosis,apoptosis,pyroptosis,ferroptosis,neutrophil inflammatory cell death(NETosis),cuproptosis,and widespread apoptosis(PANoptosis),as well as their relationship with infectious diseases.

关 键 词：程序性细胞死亡 细胞凋亡 细胞焦亡 铁死亡 中性粒细胞炎症性死亡 铜死亡 细胞广泛凋亡 免疫细胞膜Fcγ受体 

分 类 号：R363[医药卫生—病理学]