自噬对前列腺癌双重调控机制及中医药干预的研究进展  

The Research Progress of Dual-Regulation Mechanism of Autophagy inProstate Cancer and Intervention of Chinese Herbal Medicine

作　　者：徐佳[1] 李琦[1] XU Jia;LI Qi(Department of Clinical Laboratory of Xiyuan Hospital,China Academy of ChineseMedical Sciences,Beijing 100091,China)

机构地区：[1]中国中医科学院西苑医院检验科,北京100091

出　　处：《标记免疫分析与临床》2022年第10期1773-1776,共4页Labeled Immunoassays and Clinical Medicine

基　　金：中国中医科学院西苑医院苗圃课题(编号:2019XYMP-07)。

摘　　要：前列腺癌是最常见的恶性肿瘤之一,在全球男性癌症相关死亡中排名第二。雄激素剥夺治疗在大多数患者中可行,但当疾病进展为去势抵抗性前列腺癌时,患者对激素治疗产生耐药性,增加了治疗难度。近年来研究发现自噬和相关分子途径在肿瘤进展中起重要作用,其对前列腺癌的影响也受到广泛关注。本文主要阐述自噬对前列腺癌的双重调控作用及中医药的干预作用,为进一步探讨中医药在前列腺癌治疗中的作用及确定去势抵抗性前列腺癌治疗的新靶点提供理论依据和思路。Prostate cancer is one of the most common malignancies and ranks the top second in cancer-related deaths among male population worldwide.Androgen deprivation therapy is feasible in most patients,but when the disease progresses to castration-resistant prostate cancer,patients become resistant to hormone therapy,making the treatment more difficult.In recent years,autophagy and related molecular pathways have been found to play an important role in tumor progression,and their effects on prostate cancer have been widely noticed.In this paper,the dual-regulatory effect of autophagy on prostate cancer and the intervention effect of Chinese medicine were discussed,so to provide a theoretical basis and thoughts for further exploring the role of Chinese medicine in the treatment of prostate cancer and identifying new targets for the treatment of castration-resistant prostate cancer.

关 键 词：中医药 自噬 去势抵抗性前列腺癌 双重作用机制 

分 类 号：R737.25[医药卫生—肿瘤]