前列腺骨外尤文肉瘤/PNET根治术后腹腔转移报道1例  

Peritoneal Metastasis After Radical Resection of ExtraosseousEwing Sarcoma/PNET of Prostate:a Case Report

作　　者：逄瑷博 吕俊刚[3] 凌存保[1] 黄薇[1] 吴洋洋 张桐硕 田亚平[1] 张春燕[1] PANG Aibo;LYU Jungang;LING Cunbao;HUANG Wei;WU Yangyang;ZHANG Tongshuo;TIAN Yaping;ZHANG Chunyan(Birth Defects Prevention and Control Technology Research Center,Medical Research and Innovation Department,Chinese PLA General Hospital,Beijing 100853,China;Graduate School,Chinese PLA General Hospital,Beijing 100853,China;The Third Department of Internal Medicine,Beijing Corps Hospital of ChinesePeople’s Armed Police Force,Beijing 100027,China;Department of Clinical Laboratory and Pathology,Jiangsu Provincial CorpsHospital of Chinese People’s Armed Police Force,Yangzhou 225003,China)

机构地区：[1]解放军总医院医学创新研究部出生缺陷防控技术研究中心,北京100853 [2]解放军医学院,北京100853 [3]武警北京总队医院内三科,北京100027 [4]武警江苏总队医院检验与病理科,江苏扬州225003

出　　处：《标记免疫分析与临床》2022年第10期1794-1797,共4页Labeled Immunoassays and Clinical Medicine

基　　金：国家重点研发计划“主动健康和老龄化科技应对”重点专项(老年前列腺增生早期诊断及风险评估生物标志物的发现及产品研发)(编号:2021YFC2009300)。

摘　　要：目的探讨前列腺原始神经外胚层瘤临床表现、病理学特点、诊断标准及治疗与预后,以提高对本病的诊疗水平。方法回顾性分析我院前列腺骨外尤文肉瘤/原始神经外胚层瘤(E-EWS/PNET)1例。结果我院病例从确诊至今已随访52个月,术后16月复查发现盆腔肿瘤复发腹腔转移,目前国内文献报道最长生存期为随访至12个月。结论前列腺超声、CT、MRI可用于E-EWS/PNET筛查,盆腔MRI为该病诊断提供最有效的影像证据。结合血清PSA和前列腺特异性酸性磷酸酶有助于鉴别诊断,病理活检为诊断金标准。早期诊断、采用手术联合放化疗及免疫治疗可以延长寿命、改善预后。Objective To investigate the clinical manifestations,pathological characteristics,diagnostic criteria,treatment and prognosis of primitive neuroectodermal tumor of the prostate,so as to improve the diagnosis and treatment of this disease.Methods A case of extraosseous Ewing sarcoma/primitive neuroectodermal tumor of prostate(E-EWS/PNET)in our hospital was analyzed retrospectively.Results The study patients in our hospital have been followed up for 52 months since the diagnosis date.The recurrence and periloneal metastasis of pelvic tumors were found 16 months after operation.To our knowledge,the longest survival period reported in domestic literature during followed-up is 12 months.Conclusion Ultrasound,CT and MRI can be used for PNET screening.Pelvic MRI provides the most effective imaging evidence for the diagnosis.The combination of serum PSA and prostate specific acid phosphatase are helpful for differential diagnosis,and pathological biopsy is the gold standard for diagnosis.Early diagnosis,surgery combined with radiotherapy,chemotherapy and immunotherapy can prolong life span and improve prognosis.

关 键 词：排尿困难 前列腺恶性肿瘤 尤文肉瘤 原始神经外胚层瘤 

分 类 号：R737.25[医药卫生—肿瘤]