A useful toolbox for the detection of SCF E3 ligase activity  

作　　者：Federica Casagrande Qi Xie Giovanna Serino 

机构地区：[1]Dipartimento di Biologia e Biotecnologie“C.Darwin,”Sapienza Università,di Roma,Piazzale Aldo Moro 5,00185 Rome,Italy [2]State Key Laboratory of Plant Genomics,Institute of Genetics and Developmental Biology,The Innovative Academy of Seed Design,Chinese Academy of Sciences,Beijing 100101,China

出　　处：《Molecular Plant》2022年第11期1654-1655,共2页分子植物（英文版）

摘　　要：Since its discovery about 50 years ago,the ubiquitin-proteasome system(UPS)has not stopped to surprise us for its level of sophistication and complexity in achieving substrate-specific protein degradation(Vierstra,2009).At the heart of this system lies the concerted activity of three major classes of enzymes:ubiquitin activators(E1),ubiquitin conjugators(E2),and ubiquitin ligases(or E3).E3s,together with selected E2s,are responsible for promoting the formation of a ubiquitin chain on a specific protein substrate.

关 键 词：stopped LIGASE UBIQUITIN 

分 类 号：Q94[生物学—植物学]