云南高校图书馆联盟文献共享服务平台- LIGASE

LIGASE: 作品数：60被引量：148H指数：7; 导出分析报告; 相关作者：何牡丹魏志强朱作言孙永华王厚鹏更多>>; 相关机构：同济大学中国科学院大学湖北医药学院附属太和医院中国科学院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划北京市自然科学基金国家高技术研究发展计划更多>>

Function,mechanism and drug discovery of ubiquitin and ubiquitin-like modification with multiomics profiling for cancer therapy被引量：3: 《Acta Pharmaceutica Sinica B》2023年第11期4341-4372,共32页Yanyu Jiang Shuaishuai Ni Biying Xiao Lijun Jia; National Natural Science Foundation of China (Grants 81820108022,82003297 and 22177076);Innovation Program of Shanghai Municipal Education Commission (2019-01-07-00-10-E00056,China);Shanghai Frontiers Science Center of Disease and Syndrome Biology of Inflammatory Cancer Transformation (2021KJ03-12,China);The Scientific and Technological Innovation Action Plan of Science and Technology Commission of Shanghai (20JC1411300,China);ChenGuang project supported by Shanghai Municipal Education Commission and Shanghai Education Development Foundation (19CG49,China).; Ubiquitin(Ub)and ubiquitin-like(Ubl)pathways are critical post-translational modifications that determine whether functional proteins are degraded or activated/inactivated.To date,>600 associated enzymes have been rep...; 关键词：Ub and Ubl modifications Ub-activating enzyme Ub-conjugating enzyme Ub ligase Multiomics analyses Drug discovery Small molecule inhibitor Molecular glue

A useful toolbox for the detection of SCF E3 ligase activity: 《Molecular Plant》2022年第11期1654-1655,共2页Federica Casagrande Qi Xie Giovanna Serino; Since its discovery about 50 years ago,the ubiquitin-proteasome system(UPS)has not stopped to surprise us for its level of sophistication and complexity in achieving substrate-specific protein degradation(Vierstra,200...; 关键词：stopped LIGASE UBIQUITIN

Colorimetric and electrochemical detection of ligase through ligation reaction-induced streptavidin assembly: 《Chinese Chemical Letters》2022年第6期3151-3155,共5页Yaliang Huang Ting Sun Wendi Li Lin Liu Gang Liu Xinyao Yi Jianxiu Wang; the National Natural Science Foundation of China(Nos.22076221,21876208);the Program for Innovative Research Team of Science and Technology in the University of Henan Province(No.21IRTSTHN005);the Hunan Provincial Science and Technology Plan Project,China(No.2019TP1001)。; We propose a concept for ligase detection by conversion of aggregation-based homogeneous analysis into surface-tethered electrochemical assay through streptavidin(SA)-biotin interaction.Sortase A(Srt A)served as the m...; 关键词：LIGASE Electrochemical analysis STREPTAVIDIN Gold nanoparticles Colorimetric assay Electrochemical impedance spectroscopy

Discovery of a small molecule inhibitor of cullin neddylation that triggers ER stress to induce autophagy被引量：4: 《Acta Pharmaceutica Sinica B》2021年第11期3567-3584,共18页Yanan Li Chaorong Wang Tiantian Xu Peichen Pan Qing Yu Lei Xu Xiufang Xiong Tingjun Hou Sunliang Cui Yi Sun; National Key R&D Program of China(2016YFA0501800 to Yi Sun)for financial support。; Protein neddylation is catalyzed by a three-enzyme cascade,namely an E1 NEDD8-activating enzyme(NAE),one of two E2 NEDD8 conjugation enzymes and one of several E3 NEDD8 ligases.The physiological substrates of neddylat...; 关键词：AUTOPHAGY Cullin RING ligase ER stress mTORC1 NEDDYLATION Small molecule inhibitor

Polyglutamylase activity of tubulin tyrosine ligase-like 4 is negatively regulated by the never in mitosis gene A family kinase never in mitosis gene A-related kinase 5: 《World Journal of Biological Chemistry》2021年第3期38-51,共14页Talita Diniz Melo-Hanchuk Jörg Kobarg; Fundação de AmparoàPesquisa do Estado São Paulo(FAPESP,São Paulo,Brazil)through Grant Temático,No.2017/03489-1.; BACKGROUND Tubulins,building blocks of microtubules,are modified substrates of diverse post-translational modifications including phosphorylation,polyglycylation and polyglutamylation.Polyglutamylation of microtubules...; 关键词：KINASE Polyglutamylation Never in mitosis gene A-related kinase 5 Tubulin tyrosine ligase-like 4 Microtubules Post translational regulation

APPLE SUMO E3 REGULATES LIGASE MDSIZ1 NEGATIVELY DROUGHT TOLERANCE: 《Frontiers of Agricultural Science and Engineering》2021年第2期247-261,共15页Baohua CHU Jia SUN Huan DANG Ziqing MA Shuang ZHAO Qingmei GUAN Xuewei LI; the National Natural Science Foundation of China(31872080);the Start-up Funds of Northwest A&F university to Xuewei Li(2452020216).; Drought stress typically causes heavy losses in apple production and uncovering the mechanisms by which apple tolerates drought stress is important in apple breeding.MdSIZl is a SUMO(small ubiquitin-like modifier)E3 l...; 关键词：APPLE drought tolerance gene expression MdSIZ1

A rice tubulin tyrosine ligase-like 12 protein affects the dynamic and orientation of microtubules: 《Journal of Integrative Plant Biology》2021年第5期848-864,共17页Kunxi Zhang Xin Zhu Steffen Durst Petra Hohenberger Min‐Jung Han Gynheung An Vaidurya PSahi Michael Riemann Peter Nick; This work was supported by a fellowship from the the Chinese Scholarship Council to Kunxi Zhang;Open access funding enabled and organized by Projekt DEAL。; The detyrosination/retyrosination cycle is the most common post-translational modification of α-tubulin.Removal of the conserved C-terminal tyrosine of α-tubulin by a still elusive tubulin tyrosine carboxypeptidase,...; 关键词：microtubule PHRAGMOPLAST RICE tobacco BY-2 tubulin detyrosination tubulin tyrosine carboxypeptidase tubulin tyrosine ligase tubulin tyrosine ligase-like 12

Degradation of proteins by PROTACs and other strategies被引量：32: 《Acta Pharmaceutica Sinica B》2020年第2期207-238,共32页Yang Wang Xueyang Jiang Feng Feng Wenyuan Liu Haopeng Sun; the support from grants(Nos.81573281)of National Natural Science Foundation of China;support from Double First-Class initiative Innovation team project of China Pharmaceutical University(Nos.CPU2018GF11 and CPU2018GY34,China).; Abnormal protein expression or activities are associated with many diseases,especially cancer.Therefore,down-regulating the proteins involved in cancer cell survival proved to be an effective strategy for cancer treat...; 关键词：PROTEIN DEGRADATION PROTAC UBIQUITIN-PROTEASOME system E3 UBIQUITIN LIGASE Target PROTEIN Heterobifunctional molecule

The bacterial RNA ligase RtcB accelerates the repair process of fragmented rRNA upon releasing the antibiotic stress: 《Science China(Life Sciences)》2020年第2期251-258,共8页Muhammad Ramzan Manwar Changjun Shao Xing Shi Jian Wang Qiang Lin Yigang Tong Yu Kang Jun Yu; supported by the National Key Research and Development Program of China(2016YFC0903800);the National Scientific Foundation of China(31470180,31471237,31671350);the Programs of Beijing Municipal Science and Technology Project(Z171100001317011);the Scientific Research Project of Public Welfare Industry(2013FY114300,201402018);the Key Research Program of Frontier Sciences,the Chinese Academy of Sciences(QYZDY-SSWSMC017)。; RtcB, a highly conserved RNA ligase, is found in all three domains of life, and demonstrated to be an essential tRNA splicing component in archaea and metazoans. However, the biological functions of RtcB in bacteria, ...; 关键词：RtcB bacteria RNA LIGASE stress response RIBOSOMAL RNA RNA repair

Cytochrome P450 endoplasmic reticulumassociated degradation(ERAD): therapeutic and pathophysiological implications被引量：7: 《Acta Pharmaceutica Sinica B》2020年第1期42-60,共19页Doyoung Kwon Sung-Mi Kim Maria Almira Correia; supported by NIDDK Center Grant DK26743;supported by NIH Grants GM44037 and DK26506(USA)to Maria Almira Correia.; The hepatic endoplasmic reticulum(ER)-anchored cytochromes P450(P450s)are mixedfunction oxidases engaged in the biotransformation of physiologically relevant endobiotics as well as of myriad xenobiotics of therapeutic...; 关键词：CYTOCHROMES P450 Endoplasmic reticulumassociated DEGRADATION CHIP E3 UBIQUITIN LIGASE gp78/AMFR E3 UBIQUITIN LIGASE JNK1 AMPK1 Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis

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