NEDDYLATION

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PDK1 neddylation by Smurf1 drives Akt activation
《Cell Research》2025年第2期95-96,共2页Rajesh Kumar Manne Rajni Kant Hui-Kuan Lin 
The PI3K/Akt pathway,one of the most frequently dysregulated signaling pathways in various cancers,plays a key role in tumorigenesis and resistance to chemotherapy.Recent discovery highlights an important regulatory s...
关键词：PI3K/AKT CHEMOTHERAPY ACTIVATION 
Neddylation Regulation of Immune Responses
《Research》2024年第3期545-559,共15页Hongmei Mao Xin Lin Yi Sun 
the funds from National Natural Science Foundation of China(92253203 and U22A20317)to Y.S.;the Zhejiang Provincial Natural Science Foundation of China(LD22H300003)to Y.S.;the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(2022R01002)to Y.S.;a grant from Research Center for Life Science and Human Health,Binjiang Institute of Zhejiang University(ZY202205SMKY007)to Y.S.
Neddylation plays a vital role in post-translational modification, intricately shaping the regulation of diverse biological processes, including those related to cellular immune responses. In fact, neddylation exerts ...
关键词：ACTIVATION thereby initiating 
The Functional Redundancy of Neddylation E2s and E3s in Modulating the Fitness of Regulatory T Cells
《Research》2024年第2期373-387,共15页Di Wu Yi Sun 
funded by the National Key R&D Program of China(2021YFA1101000 and 2022YFC3401500 to Y.S.);National Natural Science Foundation of China(82172699 and 81801567 to D.W.and U22A20317 and 92253203 to Y.S.);Zhejiang Provincial Natural Science Foundation of China(LY21H100005 to D.W.and LD22H300003 to Y.S.).
Neddylation is necessary for activation of Cullin-RING ligases(CRLs),which degrade various immune regulatory proteins.Our recent study showed that while depletion of neddylation E2-E3 pair Ube2f-Sag in regulatory T(T_...
关键词：FOXP3 INFLAMMATION markedly 
Protein neddylation and its role in health and diseases被引量：1
《Signal Transduction and Targeted Therapy》2024年第5期1869-1904,共36页Shizhen Zhang Qing Yu Zhijian Li Yongchao Zhao Yi Sun 
This work was funded in part by the National Key R&D Program of China(grants 2022YFC3401500 to Y.S.and Y.Z.,and 2021YFA1101000 to Y.S.);the National Natural Science Foundation of China(grants 92253203 and U22A20317 to Y.S.,92053117 and 81972591 to Y.Z.,82202838 to S.Z.,and 82102749 to Q.Y.);Zhejiang Provincial Natural Science Foundation of China(grant LD22H300003 to Y.S.,LZ22H160003 to Y.Z.);Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(grant 2022R01002 to Y.S.).
NEDD8(Neural precursor cell expressed developmentally downregulated protein 8)is an ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate through a process known as neddylation,...
关键词：NEDD8 ATTACHED ATTRACTIVE 
Neddylation suppression by a macrophage membrane-coated nanoparticle promotes dual immunomodulatory repair of diabetic wounds被引量：1
《Bioactive Materials》2024年第4期366-380,共15页Ruiyin Zeng Bin Lv Ze Lin Xiangyu Chu Yuan Xiong Samuel Knoedler Faqi Cao Chuanlu Lin Lang Chen Chenyan Yu Jiewen Liao Wu Zhou Guandong Dai Mohammad-Ali Shahbazi Bobin Mi Guohui Liu 
supported by the National Science Foundation of China(No.82272491,No.82072444);the Wuhan Science and Technology Bureau(2022020801020464);the Department of Science and Technology of Hubei Province(No.2021CFB425);Chinese Pharmaceutical Association Hospital Pharmacy department(No.CPA-Z05-ZC-2022-002);Hubei Province Unveiling Science and Technology Projects(No.2022-35);Natural Science Foundation of Shenzhen Municipality(JCYJ20220531094802005);Medical Research Foundation of Guangdong Province(B2022242);Scientific Research Project in Health System of Pingshan District(202218).
Oxidative stress,infection,and vasculopathy caused by hyperglycemia are the main barriers for the rapid repair of foot ulcers in patients with diabetes mellitus(DM).In recent times,the discovery of neddylation,a new t...
关键词：Diabetes Biomimetic nanoparticle Macrophage polarization Macrophages cell membranes Wound healing 
肺动脉高压大鼠模型中PKM2 Neddylation修饰促进右心室纤维化的研究
《医学分子生物学杂志》2024年第2期108-114,共7页郭文昀 王丽霞 王金琳 
甘肃省自然科学基金(No.22JR5RA012);联勤保障部队第940医院院内项目(No.2021yxky080)。
目的探究PKM2拟素化(neddylation)修饰对肺动脉高压大鼠右心室纤维化的影响。方法将SD大鼠随机分为对照组、模型组和MLN4924组,HE染色法检测肺动脉,Masson染色检测右心室纤维化程度。提取大鼠原代心脏成纤维细胞,免疫荧光法检测α-平滑...
关键词：肺动脉高压 PKM2 拟素化修饰 右心室纤维化 
Neddylation is a novel therapeutic target for lupus by regulating double negative T cell homeostasis被引量：1
《Signal Transduction and Targeted Therapy》2024年第2期738-750,共13页Yun Zhang Lijun Du Chenxi Wang Zhangsheng Jiang Qingchi Duan Yiping Li Zhijun Xie Zhixing He Yi Sun Lin Huang Liwei Lu Chengping Wen 
supported by Regional Innovation and Development Joint Fund of the National Foundation of China(U21A20402)to C.W.;National Natural Science Foundation of China(No.82074375);the Research Project of Zhejiang Chinese Medical University(No.2023JKZDZC01)to Y.Z.;Chongqing International Institute for Immunology(2020YJC10)to L.L.;National Natural Science Foundation of China(No.82074217)to Z.H.
Systemic lupus erythematosus(SLE),a severe autoimmune disorder,is characterized by systemic inflammatory response,autoantibody accumulation and damage to organs.The dysregulation of double-negative(DN)T cells is consi...
关键词：INACTIVATION DOUBLE finding 
Arctigenin impairs UBC12 enzyme activity and cullin neddylation to attenuate cancer cells被引量：1
《Acta Pharmacologica Sinica》2023年第3期661-669,共9页Yi-fan Chen Run-zhi Liu Wen-wen Ying Yue-ning Yang Sen-feng Xiang Xue-jing Shao Ji Cao Yan-qi Zhang Bo Yang Qiao-jun He Mei-dan Ying 
the Zhejiang Provincial Natural Science Foundation of China(No.LD21H310001);the Fundamental Research Funds for the Central Universities(No.2021XZZX037);the Zhejiang Science and Technology Program of Traditional Chinese Medicine(No.2022zQ064);Westlake Laboratory(Westlake Laboratory of Life Sciences and Biomedicine);Leading Talent of"Ten Thousand Plan"-National High-Level Talents Special Support Plan.
Neddylation is a type of posttranslational protein modification that has been observed to be overactivated in various cancers.UBC12 is one of two key E2 enzymes in the neddylation pathway.Reports indicate that UBC12 d...
关键词：UBC12 ARCTIGENIN NEDDYLATION cancer therapy PDCD4 
Neddylation通过改善线粒体自噬缓解颈动脉粥样硬化及相关机制研究
《中文科技期刊数据库（全文版）医药卫生》2022年第12期33-37,共5页胡浩 安天志 
探讨糖尿病下肢动脉内皮炎症与成熟树突状细胞外泌体的关系。方法 首先用 Transwell系统和外泌体释放抑制剂GW4869来验证内皮炎症与成熟树突状细胞外泌体之间的关系;其次,从骨髓来源树突状细胞(BMDC)中分离出称为 DCexos的外泌体,并利用...
关键词：NEDDYLATION 线粒体自噬 动脉粥样硬化 
Pro-senescence neddylation inhibitor combined with a senescence activated β-galactosidase prodrug to selectively target cancer cells被引量：1
《Signal Transduction and Targeted Therapy》2022年第10期3645-3648,共4页Shuaishuai Ni Qian Liu Xin Chen Lele Ding Lili Cai Fei Mao Donglei Shi Robert M.Hoffman Jian Li Lijun Jia 
supported by the National Natural Science Foundation of China(Grant Nos.81820108022,22177076,22037002);Innovation Program of Shanghai Municipal Education Commission(2019-01-07-00-10-E00056,2021-01-07-00-02-E00104);The Scientific and Technological Innovation Action Plan of Science and Technology Commission of Shanghai(20JC1411300);Shanghai Frontiers Science Center of Disease and Syndrome Biology of Inflammatory Cancer Transformation(2021KJ03-12);National Thirteenth Five-Year Science and Technology Major Special Project for New Drug and Development(2017ZX09304001);the Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism(2021 Sci&Tech 03-28);the Innovative Research Team of High-level Local Universities in Shanghai and the Chinese Special Fund for State Key Laboratory of Bioreactor Engineering(2060204).
Dear Editor,Targeting senescence therapy is a promising anticancer strategy by arresting the cell-cycle and inducing cellular senescence.However,senescent cells can promote malignancy and drug resistance.1,2 Thus,with...
关键词：viable cancer eliminate 
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