ARCTIGENIN

作品数：13被引量：68H指数：4
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相关领域：医药卫生更多>>
相关作者：赵宇峰刘志强刘淑莹于湛服部征雄更多>>
相关机构：中国科学院大学富山医科药科大学皖南医学院弋矶山医院中国人民解放军更多>>
相关期刊：《Medicinal Plant》《Nano-Micro Letters》《Chinese Journal of Natural Medicines》《Acta Pharmacologica Sinica》更多>>
相关基金：国家自然科学基金广东省自然科学基金更多>>
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Pharmacological Activities and Molecular Mechanisms of Arctigenin
《Medicinal Plant》2023年第2期104-106,112,共4页Wenshuang HOU Jinglong CAO Jian LIU Hui XUE Yannan LI Chenghao JIN 
Supported by the Talent Training Program for the Reform and Development of Local Colleges and University of the Central Government(2020GSP16)。
Arctigenin has a variety of pharmacological effects,such as anti-inflammatory,anti-tumor,antiviral and hypoglycemic.In this paper,the pharmacological effects and mechanisms of arctigenin were reviewed,in order to prov...
关键词：ARCTIGENIN ANTI-TUMOR ANTI-INFLAMMATION ANTI-VIRUS Hypoglycemic effect 
Arctigenin impairs UBC12 enzyme activity and cullin neddylation to attenuate cancer cells被引量：1
《Acta Pharmacologica Sinica》2023年第3期661-669,共9页Yi-fan Chen Run-zhi Liu Wen-wen Ying Yue-ning Yang Sen-feng Xiang Xue-jing Shao Ji Cao Yan-qi Zhang Bo Yang Qiao-jun He Mei-dan Ying 
the Zhejiang Provincial Natural Science Foundation of China(No.LD21H310001);the Fundamental Research Funds for the Central Universities(No.2021XZZX037);the Zhejiang Science and Technology Program of Traditional Chinese Medicine(No.2022zQ064);Westlake Laboratory(Westlake Laboratory of Life Sciences and Biomedicine);Leading Talent of"Ten Thousand Plan"-National High-Level Talents Special Support Plan.
Neddylation is a type of posttranslational protein modification that has been observed to be overactivated in various cancers.UBC12 is one of two key E2 enzymes in the neddylation pathway.Reports indicate that UBC12 d...
关键词：UBC12 ARCTIGENIN NEDDYLATION cancer therapy PDCD4 
A composite arctigenin/caffeine/glucose formulation enhances anti-fatigue effect被引量：1
《Food Bioscience》2022年第5期584-592,共9页Wanbo Zeng Le Sun Huimin Zhu Xiaowen Wu Lijia Xu Liang Xu 
supported by grants from Beijing Natural Science Foundation(7202146);National Science&Technology Fundamental Resources Investigation Program of China(2018FY100702).
Fatigue is a comprehensive response to a variety of physiological and biochemical changes in the body.Combining strategies addressing relevant key factors simultaneously may enhance anti-fatigue efficiency.In this stu...
关键词：Bioinformatics analysis ANTI-FATIGUE ARCTIGENIN Antioxidant capacity PI3K-AKT 
Arctigenin attenuates paraquat-induced human lung epithelial A549 cell injury by suppressing ROS/p38 mitogen-activated protein kinases-mediated apoptosis被引量：3
《World Journal of Emergency Medicine》2022年第5期373-378,共6页Chao Liu Zhao-rui Sun Meng-meng Wang Zhi-zhou Yang Wei Zhang Yi Ren Xiao-qin Han Rui Liu Quan Li Shi-nan Nie 
This work was supported by the National Natural Science Foundation of China(82172182 and 82102311);Social Development Projects of Jiangsu Province(BE2017720);Natural Science Foundation of Jiangsu Province(BK20190247);Science Foundation of Jiangsu Health Commission(H2018039);Jiangsu Postdoctoral Research Foundation(2018K048A and 2020Z193).
BACKGROUND:Paraquat(PQ)-induced acute lung injury(ALI)and pulmonary fi brosis are common diseases with high mortality but without eff ective antidotes in emergency medicine.Our previous study has proved that arctigeni...
关键词：PARAQUAT A549 cells ARCTIGENIN Reactive oxygen species Mitogen-activated protein kinases Apoptosis 
Pharmacokinetics of Arctigenin in Fructus Arctii Extract in Piglets
《Agricultural Biotechnology》2020年第6期27-30,47,共5页Bin HE Lijun WU Xiabing CHEN Wenhai YANG Zhiyong SHAO Hua ZHOU Sijiu WANG Jie CHEN Erguang JIN Weiwen TONG 
Hubei Provincial Technical Innovation Major Project(2019AEE006);Wuhan Animal and Poultry Chinese Herbal Medicine Development Engineering Technology Research Center(2014021511020460);Hubei Provincial Central Government Guiding Local Science and Technology Development Fundation of China(2020ZYYD029)。
[Objectives]This study was conducted to investigate the pharmacokinetic characteristics of arctigenin from water extract of Fructus Arctii in piglets,understand its absorption,distribution,transformation and excretion...
关键词：Fructus Arctii ARCTIGENIN PIGLETS PHARMACOKINETICS 
Synthesis and Characterization of a Silica-Based Drug Delivery System for Spinal Cord Injury Therapy被引量：1
《Nano-Micro Letters》2019年第2期61-80,共20页Guodong Sun Shenghui Zeng Xu Liu Haishan Shi Renwen Zhang Baocheng Wang Changren Zhou Tao Yu 
supported by the National Natural Science Foundation of China(Nos.31670969,51302089,and 31571030);the Fundamental Research Funds for the Central Universities(No.21617428);Key Program of Traditional Chinese Medicine of Guangdong Province(No.20173018);The Science and Technology Program of Jiangmen City of China(No.2017A2004);Natural Science Foundation of Guangdong Province(No.2018A030313576);Science and Technology Program of Guangzhou(No.201803010001)
Acute inflammation is a central component in the progression of spinal cord injury(SCI).Anti-inflammatory drugs used in the clinic are often administered systemically at high doses,which can paradoxically increase inf...
关键词：SILICA Drug delivery Spinal cord injury ARCTIGENIN ASTROCYTES 
Overview of the anti-inflammatory effects, pharmacokinetic properties and clinical efficacies of arctigenin and arctiin from Arctium lappa L被引量：37
《Acta Pharmacologica Sinica》2018年第5期787-801,共15页Qiong GAO Mengbi YANG Zhong ZUO 
Arctigenin （AR） and its glycoside, arctiin, are two major active ingredients of Arctium lappa L （A lappa）, a popular medicinal herb and health supplement frequently used in Asia. In the past several decades, bioac...
关键词：ARCTIGENIN ARCTIIN Arctium lappa L Fructus Arctii anti-inflammatory agents PHARMACOKINETICS clinical efficacy 
Mathematical modeling for of arctigenin from acidultrasonic-assisted extractionhydrolyzed FructusArctii
《Journal of Southeast University(English Edition)》2017年第3期362-369,共8页Dai Lin Zhang Yong Hu Chi Qian Hongliang Wang Zhixiang 
The National Natural Science Foundation of China(No.21406272,21676291);the Fundamental Research Funds for the Central Universities(No.2632017ZD01);Jiangsu Planned Projects for Postdoctoral Research Funds(No.1402060B)
A mathematical model based on Fick's first lawwas established to describe the process of ultrasonic-assisted extraction of arctigenin from acid hydrolyzed FructusArctii.Acid hydrolization with hydrochloric acid promot...
关键词：FructusArctii acid hydrolysis ultrasonic-assisted extraction ARCTIGENIN mathematical model 
A novel arctigenin-containing latex glove prevents latex allergy by inhibiting typeⅠ/Ⅳallergic reactions被引量：3
《Chinese Journal of Natural Medicines》2016年第3期185-195,共11页WANG Yong-Xin XUE Dan-Ting LIU Meng ZHOU Zheng-Min SHANG Jing 
supported by National Science and Technology Infrastructure Program of China(No.2012BAI30B001);Technological Innovation Team of Jiangsu Higher Education;National Natural Science Foundation of China(Nos.30873156;30672524);New Century Excellent Talents in University(NCET-07-0851);Mega-projects of Science Research for the 12th Five-Year Plan of China(No.2011AX09401-007)
The present study aimed at developing a natural compound with anti-allergic effect and stability under latex glove manufacturing conditions and investigating whether its anti-allergic effect is maintained after its ad...
关键词：Latex allergy ARCTIGENIN RBL-2H3 cell Mouse primary spleen lymphocytes 
Arctigenin enhances swimming endurance of sedentary rats partially by regulation of antioxidant pathways被引量：14
《Acta Pharmacologica Sinica》2014年第10期1274-1284,共11页Ruo-ming WU Yan-yan SUN Ting-ting ZHOU Zhi-yuan ZHU Jing-jing ZHUANG Xuan TANG Jing CHEN Li-hong HU Xu SHEN 
Acknowledgements This work was supported by the National Natural Science Foundation of China （No 81220108025 and 81373461） and the Science and Technology Commission of Shanghai Municipality （12431900300）.
Aim： Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan found in traditional Chinese herbs, has been determined to exhibit a variety of pharmacological activities, including anti-tumor, anti-inflammation, neu...
关键词：ARCTIGENIN skeletal muscle weight-loaded forced swimming test fatigue physical endurance ROS ANTIOXIDANT AMPK PPARΑ Nrf2 
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