A composite arctigenin/caffeine/glucose formulation enhances anti-fatigue effect  

作　　者：Wanbo Zeng Le Sun Huimin Zhu Xiaowen Wu Lijia Xu Liang Xu 

机构地区：[1]State Key Laboratory of Toxicology and Medical Countermeasures,Beijing Institute of Pharmacology and Toxicology,Beijing,100850,China [2]Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing,100193,China [3]Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine,Ministry of Education,Beijing,100193,China

出　　处：《Food Bioscience》2022年第5期584-592,共9页食品生物科学（英文）

基　　金：supported by grants from Beijing Natural Science Foundation(7202146);National Science&Technology Fundamental Resources Investigation Program of China(2018FY100702).

摘　　要：Fatigue is a comprehensive response to a variety of physiological and biochemical changes in the body.Combining strategies addressing relevant key factors simultaneously may enhance anti-fatigue efficiency.In this study,we aimed to develop new anti-fatigue agents with combining strategy based on bioinformatics analysis.Result indicated PI3k-Akt,cAMP,and p53 signaling pathway-related energy metabolism and antioxidant capacity were involved in exercise-induced physiological changes.A new representative complex agent(Z-005,containing arctigenin,caffeine,and glucose)addressing these key factors as well as central excitation was developed and tested.Z-005 showed a synergistic effect,greatly enhancing anti-fatigue efficiency than single components,in a mouse running wheel test.Mouse exhaustion distances were 2.40-fold greater than the control in the Z-005 group.Z-005 excited the central nervous system,increased the plasma superoxide dismutase and catalase concentrations,reduced lactic acid accumulation,maintained the glycogen content.Besides,the expression of key genes in PI3K,cAMP,and p53 pathways,as well as the phosphorylation of adenosine monophosphate-activated protein kinase(AMPK)were proved with enhancement by Z-005 administration.This composite formulation thus represents a new and practicable combined strategy for fatigue prevention,and the study findings can contribute to the development of treatments for fatigue-related sub-health.

关 键 词：Bioinformatics analysis ANTI-FATIGUE ARCTIGENIN Antioxidant capacity PI3K-AKT 

分 类 号：TS201.4[轻工技术与工程—食品科学]