Pharmacokinetics of Arctigenin in Fructus Arctii Extract in Piglets  

作　　者：Bin HE Lijun WU Xiabing CHEN Wenhai YANG Zhiyong SHAO Hua ZHOU Sijiu WANG Jie CHEN Erguang JIN Weiwen TONG 

机构地区：[1]Wuhan Academy of Agricultural Sciences,Wuhan 430028,China

出　　处：《Agricultural Biotechnology》2020年第6期27-30,47,共5页农业生物技术（英文版）

基　　金：Hubei Provincial Technical Innovation Major Project(2019AEE006);Wuhan Animal and Poultry Chinese Herbal Medicine Development Engineering Technology Research Center(2014021511020460);Hubei Provincial Central Government Guiding Local Science and Technology Development Fundation of China(2020ZYYD029)。

摘　　要：[Objectives]This study was conducted to investigate the pharmacokinetic characteristics of arctigenin from water extract of Fructus Arctii in piglets,understand its absorption,distribution,transformation and excretion in piglets,and provide theoretical reference for the development and clinical use of new veterinary drugs.[Methods]Six healthy piglets,weighing(30.0±5.0)kg,were selected and administered by gavage with a Fructus Arctii water extract at 1.0 g/kg·bw.Blood was collected from the anterior vena cava at different time points.The concentration of arctigenin in pig plasma was determined by HPLC.The main pharmacokinetic parameters were:absorption half-life(t1/2 ka)(0.098±0.006)h,distribution half-life(t1/2α)(0.208±0.009)h,elimination half-life(t1/2β)(23.816±2.151)h,apparent volume of distribution(Vd)(32.212±4.033)L/kg,apparent volume of distribution(Vd)(32.212±4.033)L/kg,clearance(CLb)(2.384±1.589)L/(h·kg),peak time(tmax)(0.251±0.011)h,peak concentration(Cmax)(0.560±0.063)μg/ml,and the area under the curve(AUC)at the time of drug administration(9.620±0.752)μg·h/ml.[Results]After oral administration of the water extract powder of Fructus Arctii,arctigenin showed a two-compartment model with absorption in piglets,with the characteristics of fast absorption,wide distribution and slow elimination.Arctigenin might have a hepatoenteral circulation in piglets,and the drug effect could last for a long time.[Conclusions]This study provides a theoretical basis and reference for the development and clinical use of new veterinary drugs.

关 键 词：Fructus Arctii ARCTIGENIN PIGLETS PHARMACOKINETICS 

分 类 号：S859.7[农业科学—临床兽医学]